| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4605257 | B | Binding affinity at recombinant human 6His-tagged FABP4 expressed in Escherichia coli BL21 DE3 by isothermal titration calorimetry | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 2. | ALA4605258 | B | Displacement of 1,8-ANS from recombinant human 6His-tagged FABP3 expressed in Escherichia coli BL21 DE3 incubated for 15 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 3. | ALA4605259 | B | Displacement of 1,8-ANS from recombinant human 6His-tagged FABP5 expressed in Escherichia coli BL21 DE3 incubated for 15 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based assay | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 4. | ALA4605260 | B | Selectivity index, ratio of Ki for recombinant human 6His-tagged FABP3 expressed in Escherichia coli BL21 DE3 to Ki for recombinant human 6His-tagged FABP4 expressed in Escherichia coli BL21 DE3 | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 5. | ALA4605261 | A | Cytotoxicity against human THP1 cells assessed as reduction in cell viability at 20 and 50 uM incubated for 24 hrs by CCK8 assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4605262 | F | Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced MCP1 secretion at 20 uM incubated for 18 hrs followed by LPS stimulation and measured after 6 hrs by ELISA | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA4605263 | F | Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced IL6 secretion at 20 uM incubated for 18 hrs followed by LPS stimulation and measured after 6 hrs by ELISA | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA4605264 | F | Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced MCP1 secretion incubated for 18 hrs followed by LPS stimulation and measured after 6 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4605265 | A | Cytotoxicity against mouse 3T3L1 cells assessed as reduction in cell viability at 20 and 50 uM incubated for 24 hrs by CCK8 assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4605266 | B | Inhibition of FABP4 in mouse 3T3L1 cells assessed as inhibition of forskolin-stimulated lipolysis by measuring free glycerol at 1 to 25 uM incubated for 24 hrs followed by forskolin stimulation and measured after 2 hrs | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4605267 | A | Metabolic stability in human liver microsomes assessed as half life at 0.1 uM incubated for 60 mins by LC/MS-MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4605268 | A | Metabolic stability in mouse liver microsomes assessed as half life at 0.1 uM incubated for 60 mins by LC/MS-MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4605269 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.1 uM incubated for 60 mins by LC/MS-MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4605270 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.1 uM incubated for 60 mins by LC/MS-MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 15. | ALA4605271 | A | Apparent permeability across apical to basolateral side in human Caco2 cells incubated upto 90 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4605272 | A | Efflux ratio for apparent permeability across apical to basolateral side in human Caco2 cells incubated upto 90 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4605273 | A | Half life in ICR mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4605274 | A | Tmax in ICR mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4605275 | A | Cmax in ICR mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4605276 | A | AUC (0 to 24 hrs) in ICR mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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