# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4627646 | Functional | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay | Homo sapiens | 25 | ALA4627259 | cell-based format | Scientific Literature | |
2. | ALA4627647 | Functional | Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate at 30 uM to 1 nM incubated for 1 hr followed by IP1-d2 addition by HTRF assay relative to control | Homo sapiens | 25 | ALA4627259 | cell-based format | Scientific Literature | |
3. | ALA4627648 | ADME | Drug metabolism in mouse microsomes assessed as drug turnover at 20 uM measured after 30 mins by LCMS analysis | Mus musculus | 25 | ALA4627259 | microsome format | Scientific Literature | |
4. | ALA4627649 | ADME | Drug metabolism in rat microsomes assessed as drug turnover at 20 uM measured after 30 mins by LCMS analysis | Rattus norvegicus | 25 | ALA4627259 | microsome format | Scientific Literature | |
5. | ALA4627650 | ADME | Drug metabolism in dog microsomes assessed as drug turnover at 20 uM measured after 30 mins by LCMS analysis | Canis lupus familiaris | 25 | ALA4627259 | microsome format | Scientific Literature | |
6. | ALA4627651 | ADME | Drug metabolism in human microsomes assessed as drug turnover at 20 uM measured after 30 mins by LCMS analysis | Homo sapiens | 25 | ALA4627259 | microsome format | Scientific Literature | |
7. | ALA4627652 | ADME | Clearance in rat at 1 mg/kg, iv or 10 mg/kg, po | Rattus norvegicus | 3 | ALA4627259 | organism-based format | Scientific Literature | |
8. | ALA4627653 | ADME | Volume of distribution at steady state in rat at 1 mg/kg, iv or 10 mg/kg, po | Rattus norvegicus | 3 | ALA4627259 | organism-based format | Scientific Literature | |
9. | ALA4627654 | ADME | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 3 | ALA4627259 | organism-based format | Scientific Literature | |
10. | ALA4627655 | ADME | Clearance in dog at 1 mg/kg, iv or 5 mg/kg, po | Canis lupus familiaris | 3 | ALA4627259 | organism-based format | Scientific Literature | |
11. | ALA4627656 | ADME | Volume of distribution at steady state in dog at 1 mg/kg, iv or 5 mg/kg, po | Canis lupus familiaris | 3 | ALA4627259 | organism-based format | Scientific Literature | |
12. | ALA4627657 | ADME | Oral bioavailability in dog at 5 mg/kg | Canis lupus familiaris | 3 | ALA4627259 | organism-based format | Scientific Literature | |
13. | ALA4627658 | ADME | Inhibition of CYP3A4 (unknown origin) at 10 uM relative to control | Homo sapiens | 3 | ALA4627259 | single protein format | Scientific Literature | |
14. | ALA4627659 | ADME | Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control | Homo sapiens | 3 | ALA4627259 | single protein format | Scientific Literature | |
15. | ALA4627660 | ADME | Inhibition of CYP2D6 (unknown origin) at 10 uM relative to control | Homo sapiens | 3 | ALA4627259 | single protein format | Scientific Literature | |
16. | ALA4627661 | Physicochemical | Solubility of compound at pH 2 to 7.5 | 1 | ALA4627259 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4627662 | ADME | Permeability of compound | 1 | ALA4627259 | assay format | Scientific Literature | ||
18. | ALA4627663 | Toxicity | Toxicity in rat assessed as NOAEL administered as repeated dose for 1 month | Rattus norvegicus | 1 | ALA4627259 | assay format | Scientific Literature | |
19. | ALA4627664 | Toxicity | Toxicity in dog assessed as NOAEL administered as repeated dose for 1 month | Canis lupus familiaris | 1 | ALA4627259 | assay format | Scientific Literature | |
20. | ALA4627670 | Physicochemical | Dissociation constant, pKa of compound | 2 | ALA4627259 | small-molecule physicochemical format | Scientific Literature |