# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4605389 | B | Inhibition of N-terminal His6-tagged Plasmodium falciparum DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay | Plasmodium falciparum | 71 | cell-based format | Scientific Literature | ||
2. | ALA4605390 | B | Inhibition of N-terminal His6-tagged Plasmodium vivax DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay | Plasmodium vivax | 71 | cell-based format | Scientific Literature | ||
3. | ALA4605391 | A | Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay | Homo sapiens | 72 | cell-based format | Scientific Literature | ||
4. | ALA4605392 | F | Antimalarial activity against Plasmodium falciparum 3D7 infected in human red blood cells after 72 hrs by SYBR Green 1 dye based fluorescence assay | Plasmodium falciparum | 72 | organism-based format | Scientific Literature | ||
5. | ALA4605396 | A | Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
6. | ALA4605397 | A | Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay | Rattus norvegicus | 8 | cell-based format | Scientific Literature | ||
7. | ALA4605398 | A | Inhibition of C-terminal His6-tagged dog DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assay | Canis lupus familiaris | 8 | cell-based format | Scientific Literature | ||
8. | ALA4605399 | P | Distribution coefficient, log D of compound at pH 7.4 | 26 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA4605400 | P | Kinetic solubility of compound in pH 6.5 phosphate buffered saline | 26 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA4605401 | A | Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured after 10 to 40 mins in absence of NADPH regeneration system by UPLC-MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
11. | ALA4605402 | A | Intrinsic clearance in human liver microsomes assessed as per mg protein | Homo sapiens | 26 | microsome format | Scientific Literature | ||
12. | ALA4605403 | A | Intrinsic clearance in mouse liver microsomes assessed as per mg protein | Mus musculus | 26 | microsome format | Scientific Literature | ||
13. | ALA4605404 | F | Antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 measured after 72 hrs by SYBR Green dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
14. | ALA4605405 | B | Inhibition of yeast DHODH transformed in Plasmodium falciparum D10 in presence of 10 uM proguanil | Saccharomyces cerevisiae | 2 | assay format | Scientific Literature | ||
15. | ALA4605406 | F | Antimalarial activity against Plasmodium falciparum 1D3 measured after 72 hrs by SYBR Green dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
16. | ALA4605407 | F | Antimalarial activity against Plasmodium falciparum R10C1B harboring DHODH G181C mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
17. | ALA4605408 | F | Antimalarial activity against Plasmodium falciparum R1BC1A harboring DHODH L531F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
18. | ALA4605409 | F | Antimalarial activity against Plasmodium falciparum R1AC1B harboring DHODH C276F mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
19. | ALA4605410 | F | Antimalarial activity against Plasmodium falciparum R2B harboring DHODH R265G mutant measured after 72 hrs by SYBR Green dye based fluorescence assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
20. | ALA4605411 | U | Selectivity ratio of EC50 for inhibition of yeast DHODH expressed in Plasmodium falciparum D10 in presence of 10 uM proguanil to EC50 for antimalarial activity against multidrug-resistant Plasmodium falciparum Dd2 | 2 | assay format | Scientific Literature |