# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4604217 | Binding | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation at 1 uM after 12 hrs by Western blot analysis | Homo sapiens | 3 | ALA4602651 | cell-based format | Scientific Literature | |
2. | ALA4604222 | Binding | Protac activity at CRBN/CDK9 in AR-negative human PC3 cells assessed as induction of CDK9 protein degradation at 1 uM after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4602651 | cell-based format | Scientific Literature | |
3. | ALA4604223 | Binding | Protac activity at CRBN/CDK9 in AR-negative human PC3 cells assessed as induction of CDK9 protein degradation at 30 uM after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4602651 | cell-based format | Scientific Literature | |
4. | ALA4604226 | Functional | Antiproliferative activity against AR-negative human PC3 cells assessed as reduction in cell viability after 5 days by CCK8 assay | Homo sapiens | 22 | ALA4602651 | cell-based format | Scientific Literature | |
5. | ALA4604236 | Binding | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as CDK2 degradation at 1 uM preincubated with pomalidomide for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602651 | cell-based format | Scientific Literature | |
6. | ALA4604237 | Binding | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as CDK2 degradation at 1 uM preincubated with FN-1501 for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602651 | cell-based format | Scientific Literature | |
7. | ALA4604238 | Binding | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as CDK2 degradation at 1 uM preincubated with proteasome inhibitor MG132 for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602651 | cell-based format | Scientific Literature | |
8. | ALA4604257 | Binding | Protac activity at CRBN/CDK5 in AR-negative human PC3 cells assessed as induction of CDK5 protein degradation at 1 uM after 12 hrs by Western blot analysis | Homo sapiens | 2 | ALA4602651 | cell-based format | Scientific Literature | |
9. | ALA4604268 | Binding | Protac activity at CRBN/CDK9 in AR-negative human PC3 cells assessed as induction of CDK9 protein degradation at 5 uM after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4602651 | cell-based format | Scientific Literature |