| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4606481 | T | Selectivity ratio of IC50 for inhibition of human Src expressed in Escherichia coli BL21 to IC50 for inhibition of Toxoplasma gondii full-length wild-type C-terminal His-tagged CDPK1 expressed in Escherichia coli BL21(DE3)V2RpAcYc-LIC+LamP | 3 | ALA4602732 | assay format | Scientific Literature | ||
| 2. | ALA4606482 | A | Inhibition of human Src expressed in Escherichia coli BL21 using Abltide peptide as substrate incubated for 20 to 40 mins by ELISA | Homo sapiens | 3 | ALA4602732 | assay format | Scientific Literature | |
| 3. | ALA4606483 | B | Inhibition of Toxoplasma gondii full-length C-terminal His-tagged CDPK1 G128M mutant expressed in Escherichia coli BL21(DE3)V2RpAcYc-LIC+LamP using syntide-2 peptide as substrate incubated for 20 to 40 mins by ELISA | Toxoplasma gondii | 3 | ALA4602732 | assay format | Scientific Literature | |
| 4. | ALA4606484 | A | Cytotoxicity against MDCK cells assessed as cell growth at 20 uM measured after 72 hrs by cellTiter 96 AQueous non-radioactive cell proliferation assay relative to control | Canis lupus familiaris | 4 | ALA4602732 | cell-based format | Scientific Literature | |
| 5. | ALA4606485 | F | Antiparasitic activity against Toxoplasma gondii type III CTG tachyzoites infected in HFF assessed as reduction in parasite growth | Toxoplasma gondii type III | 3 | ALA4602732 | organism-based format | Scientific Literature | |
| 6. | ALA4606486 | A | Cytotoxicity against HFF monolayers assessed as cell growth measured after 72 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 4 | ALA4602732 | cell-based format | Scientific Literature | |
| 7. | ALA4606487 | F | Antiparasitic activity against type 2 Toxoplasma gondii ME49 tachyzoites infected in HFF assessed as reduction in parasite growth | Toxoplasma gondii | 3 | ALA4602732 | organism-based format | Scientific Literature | |
| 8. | ALA4606488 | A | Protein binding in mouse brain assessed as unbound fraction | Mus musculus | 3 | ALA4602732 | tissue-based format | Scientific Literature | |
| 9. | ALA4606489 | A | Protein binding in mouse plasma assessed as unbound fraction at 2 uM measured after 4 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4602732 | cell-free format | Scientific Literature | |
| 10. | ALA4606490 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4602732 | microsome format | Scientific Literature | |
| 11. | ALA4606491 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4602732 | microsome format | Scientific Literature | |
| 12. | ALA4606492 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4602732 | microsome format | Scientific Literature | |
| 13. | ALA4606493 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4602732 | microsome format | Scientific Literature | |
| 14. | ALA4606494 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4602732 | microsome format | Scientific Literature | |
| 15. | ALA4606495 | B | Inhibition of Toxoplasma gondii full-length wild-type C-terminal His-tagged CDPK1 expressed in Escherichia coli BL21(DE3)V2RpAcYc-LIC+LamP using syntide-2 peptide as substrate incubated for 20 to 40 mins by ELISA | Toxoplasma gondii | 92 | ALA4602732 | assay format | Scientific Literature | |
| 16. | ALA4606496 | F | Antiparasitic activity against 2F clone of type 1 Toxoplasma gondii RH tachyzoites expressing beta-galactosidase infected in HFF assessed as reduction in parasite growth measured after 72 hrs by chlorophenol Red-beta-D-galactopyranoside substrate based assay | Toxoplasma gondii | 92 | ALA4602732 | organism-based format | Scientific Literature | |
| 17. | ALA4606497 | A | Half life in mouse liver microsomes at 10 uM preincubated for 10 mins followed by NADPH addition by LC-MS/MS analysis | Mus musculus | 69 | ALA4602732 | microsome format | Scientific Literature | |
| 18. | ALA4606498 | A | Half life in human liver microsomes at 10 uM preincubated for 10 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 69 | ALA4602732 | microsome format | Scientific Literature | |
| 19. | ALA4606499 | A | Inhibition of recombinant human full-length His-tagged PTK6 cytoplasmic domain expressed in baculovirus expression system at 1 uM using Fluorescein-Poly GT as substrate by Lanthascreen assay relative to control | Homo sapiens | 2 | ALA4602732 | assay format | Scientific Literature | |
| 20. | ALA4606500 | A | Inhibition of recombinant human full-length His-tagged CKepsilon expressed in baculovirus expression system at 1 uM by Lanthascreen assay relative to control | Homo sapiens | 2 | ALA4602732 | assay format | Scientific Literature |
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