# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4619530 | F | Antibacterial activity against wild type Escherichia coli ATCC 25922 at pH 7.4 by CLSI-based broth microdilution assay | Escherichia coli | 33 | organism-based format | Scientific Literature | ||
2. | ALA4619531 | F | Antibacterial activity against wild type Pseudomonas aeruginosa PAO1 K767 by CLSI-based broth microdilution assay | Pseudomonas aeruginosa | 33 | organism-based format | Scientific Literature | ||
3. | ALA4619532 | P | Solubility of the compound in pH 7 PBS incubated for 24 hrs under gently shaking condition by UPLC/UV/CLND/MS analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4619533 | P | n-Octanol-PBS buffer partition coefficient, log D of the compound at pH 7.4 after overnight incubation by LC/UV/qTOF analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA4619534 | B | Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of ATP by size exclusion HPLC analysis | Escherichia coli | 5 | protein complex format | Scientific Literature | ||
6. | ALA4619535 | B | Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA topoisomerase 4 subunit ParC/ParE using kinetoplast DNA as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr in presence of ATP by size exclusion chromatography | Escherichia coli | 5 | assay format | Scientific Literature | ||
7. | ALA4619536 | F | Antibacterial activity against wild type Klebsiella pneumoniae ATCC 43816 by CLSI-based broth microdilution assay | Klebsiella pneumoniae | 33 | organism-based format | Scientific Literature | ||
8. | ALA4619537 | F | Antibacterial activity against Pseudomonas aeruginosa K1542/K767 harboring MexB/MexXY deletion mutant by CLSI-based broth microdilution assay | Pseudomonas aeruginosa | 33 | organism-based format | Scientific Literature | ||
9. | ALA4619538 | F | Antibacterial activity against Pseudomonas aeruginosa NB52023 harboring gyrA T83I mutant/ParC S87L mutant by CLSI-based broth microdilution assay | Pseudomonas aeruginosa | 33 | organism-based format | Scientific Literature | ||
10. | ALA4619539 | F | Antibacterial activity against Escherichia coli BW25113/JW0451-2 harboring AcrB deletion mutant by CLSI-based broth microdilution assay | Escherichia coli | 27 | organism-based format | Scientific Literature | ||
11. | ALA4619540 | A | Protein binding in CD1 mouse plasma at 10 uM incubated for 4 hrs under shaking condition by LC-MS/MS analysis | Mus musculus | 3 | cell-free format | Scientific Literature | ||
12. | ALA4619541 | A | Protein binding in Sprague-Dawley rat plasma at 10 uM incubated for 4 hrs under shaking condition by LC-MS/MS analysis | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
13. | ALA4619542 | A | Protein binding in pooled human plasma at 10 uM incubated for 4 hrs under shaking condition by LC-MS/MS analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
14. | ALA4619545 | A | Apparent permeability across apical to basolateral side in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
15. | ALA4619546 | A | Efflux ratio of apparent permeability in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
16. | ALA4619547 | A | Intrinsic clearance in rat liver microsomes at 1 uM in presence of NADPH and measured up to 30 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
17. | ALA4619548 | A | Intrinsic clearance in human liver microsomes at 1 uM in presence of NADPH and measured up to 30 mins by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
18. | ALA4619549 | P | Dissociation constant, pKa of the compound by UV metric method | 3 | small-molecule physicochemical format | Scientific Literature | |||
19. | ALA4619550 | A | Intrinsic clearance in mouse liver microsomes at 1 uM in presence of NADPH and measured up to 30 mins by LC-MS/MS analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
20. | ALA4619551 | B | Inhibition of human ERG expressed in CHOK1 cells measured for 10 mins by QPatch automated patch-clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature |