#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4622222	Binding	Displacement of 2-((1E,3E,5E)-5-(3,3-Dimethyl-1-(6-((4-(((3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)pyridin-2-yl)oxy)methyl)bicyclo[2.2.2]octan-1-yl)amino)-6-oxohexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-5-sulfo-3H-indol-1-ium trifluoroacetate from biotinylated human TLR8 extracellular domain (27 to 827 residues) expressed in Drosophila S2 cells after 30 mins by europium-labeled streptavidin based TR-FRET assay	Homo sapiens	27	ALA4619804	cell-based format	Scientific Literature
2.	ALA4727484	Binding	Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production	Mus musculus	12	ALA4725311	cell-based format	Scientific Literature
3.	ALA4727485	Binding	Antagonist activity at TLR9 in mouse splenocytes assessed as inhibition of CpG1585-induced IL6 production	Mus musculus	13	ALA4725311	cell-based format	Scientific Literature
4.	ALA4727486	Binding	Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production	Homo sapiens	15	ALA4725311	tissue-based format	Scientific Literature
5.	ALA4727488	Binding	Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production	Homo sapiens	14	ALA4725311	cell-based format	Scientific Literature
6.	ALA4727489	Binding	Antagonist activity at TLR9 in human PBMC assessed as inhibition of ODN2216-induced IFNalpha production	Homo sapiens	13	ALA4725311	tissue-based format	Scientific Literature
7.	ALA4727492	ADME	AUC in BALB/c mouse at 20 mg/kg, po	Mus musculus	6	ALA4725311	organism-based format	Scientific Literature
8.	ALA4727493	ADME	Cmax in BALB/c mouse at 20 mg/kg, po	Mus musculus	6	ALA4725311	organism-based format	Scientific Literature
9.	ALA4727494	ADME	Clearance in BALB/c mouse at 5 mg/kg, iv	Mus musculus	6	ALA4725311	organism-based format	Scientific Literature
10.	ALA4727495	ADME	Volume of distribution at steady state in BALB/c mouse at 5 mg/kg, iv	Mus musculus	6	ALA4725311	organism-based format	Scientific Literature
11.	ALA4727496	ADME	Terminal half life in BALB/c mouse at 5 mg/kg, iv	Mus musculus	6	ALA4725311	organism-based format	Scientific Literature
12.	ALA4727497	ADME	Oral bioavailability in BALB/c mouse at 20 mg/kg	Mus musculus	6	ALA4725311	organism-based format	Scientific Literature
13.	ALA4727498	Binding	Antagonist activity at TLR7 ECD (unknown origin)-fused TLR9 ICD mutant (unknown origin) expressed in HEK293 cells assessed as inhibition of ssRNA40-induced NFKappaB activation	Homo sapiens	2	ALA4725311	cell-based format	Scientific Literature
14.	ALA4727499	Binding	Antagonist activity at TLR9 ECD (unknown origin)-fused TLR7 ICD mutant (unknown origin) expressed in HEK293 cells assessed as inhibition of R848-induced NFKappaB activation	Homo sapiens	2	ALA4725311	cell-based format	Scientific Literature