| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4619369 | B | Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFK substrate and ATP incubated for 30 mins by TR-FRET method | Homo sapiens | 39 | single protein format | Scientific Literature | ||
| 2. | ALA4619370 | A | Half life in C57BL/6N mouse at 2 mg/kg, po after 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 3. | ALA4619371 | A | Tmax in C57BL/6N mouse at 2 mg/kg, po after 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 4. | ALA4619372 | A | Cmax in C57BL/6N mouse at 2 mg/kg, po after 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 5. | ALA4619373 | A | AUClast in C57BL/6N mouse at 2 mg/kg, po after 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA4619375 | A | Protein binding in mouse plasma | Mus musculus | 2 | cell-free format | Scientific Literature | ||
| 7. | ALA4619376 | B | Inhibition of PKCzeta in human THP1 cells assessed as reduction in LPS-induced TNFalpha production pre-incubated for 60 mins before LPS simulations for 4 hrs by HTRF assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4619377 | B | Inhibition of PKA (unknown origin) | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 9. | ALA4619378 | B | Selectivity index, ratio of IC50 for inhibition of PKA (unknown origin) to iC50 for inhibition of recombinant human PKCzeta | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 10. | ALA4619381 | B | Inhibition of human FYN at 1.4 nM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4619382 | B | Inhibition of human TRKB at 1.4 nM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4619383 | F | Anti-inflammatory activity in DBA/1J mouse model of CFA-stimulkated collagen-induced arthritis assessed as reduction in disease progression at 3 to 30 mg/kg, po dosed twice daily after booster immunization | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4619384 | F | Anti-inflammatory activity in DBA/1J mouse model of CFA-stimulkated collagen-induced arthritis assessed as reduction in joint swelling at 3 to 30 mg/kg, po dosed twice daily after booster immunization | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4619389 | F | Anti-inflammatory activity in DBA/1J mouse model of CFA-stimulkated collagen-induced arthritis assessed as reduction in p65 Ser311 phosphorylation at 3 to 30 mg/kg, po dosed twice daily after booster immunization by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4619390 | F | Anti-inflammatory activity in DBA/1J mouse model of CFA-stimulkated collagen-induced arthritis assessed as reduction in IkappaB phosphorylation at 3 to 30 mg/kg, po dosed twice daily after booster immunization by Western blot analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4619391 | A | Volume of distribution in C57BL/6N mouse at 1 mg/kg, iv after 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4619392 | A | Clearance in C57BL/6N mouse at 1 mg/kg, iv after 0.5 to 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5127341 | B | Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFKC as substrate measured by TR-FRET assay | Homo sapiens | 6 | single protein format | Scientific Literature |
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