# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4627762 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring CD86 level at 0.1 uM after 6 hrs by flow cytometry | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
2. | ALA4627763 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring CD80 level at 0.1 uM after 6 hrs by flow cytometry | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
3. | ALA4627766 | B | Agonist activity at TLR8 in human PBMC assessed as induction of myeloid dendritic cell maturation by measuring HLA-DR level at 0.1 uM after 6 hrs by flow cytometry | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
4. | ALA4627768 | B | Agonist activity at TLR8 in human PBMC assessed as induction of myeloid dendritic cell maturation by measuring CD86 level at 0.1 uM after 6 hrs by flow cytometry | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
5. | ALA4627770 | B | Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
6. | ALA4627771 | B | Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
7. | ALA4627773 | B | Agonist activity at human TLR3 expressed in HEK293 cells by SEAP reporter gene assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
8. | ALA4627774 | B | Agonist activity at human TLR9 expressed in HEK293 cells by SEAP reporter gene assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
9. | ALA4627775 | B | Agonist activity at TLR7/TLR8 in human PBMC assessed as IFN alpha level | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
10. | ALA4627776 | B | Agonist activity at TLR7 in human PBMC assessed as IFNalpha stimulation at 10 uM | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
11. | ALA4627777 | B | Agonist activity at TLR8 in human PBMC assessed as TNFalpha level | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
12. | ALA4627778 | B | Agonist activity at TLR8 in human PBMC assessed as TNFalpha level at 10 uM | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
13. | ALA4627780 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring increase in MHC-1 level at 0.1 uM after 6 hrs by flow cytometry relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
14. | ALA4627781 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring increase in HLA-DR level at 0.1 uM after 6 hrs by flow cytometry relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature |