| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4619393 | T | Toxicity in BALB/c nude mouse xenografted with human HCT116 cells assessed as body weight loss at 25 to 50 mg/kg, ip administered every 3 days for 21 days measured on day 7 relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4619395 | B | Inhibition of human PDF expressed in Escherichia coli BL21 pLysS using formyl-Met-Ala-His-Ala peptide as substrate measured after 1 hr by fluorescamine-based fluorescence assay | Homo sapiens | 32 | assay format | Scientific Literature | ||
| 3. | ALA4619396 | F | Antiproliferative activity against human HCT116 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
| 4. | ALA4619397 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA4619398 | F | Antiproliferative activity against human SJSA1 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 6. | ALA4619399 | F | Antiproliferative activity against human HL60 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA4619400 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4619401 | A | Cytotoxicity against human MCF10A cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA4619402 | B | Inhibition of PDF in human A549 cells assessed as decrease in mtDNA encoded COX1 protein level measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4619403 | B | Inhibition of PDF in human MCF7 cells assessed as decrease in mtDNA encoded COX1 protein level measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4619406 | F | Induction of apoptosis in human A549 cells assessed as live cells at 40 uM measured after 24 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 97 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4619407 | F | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 40 uM measured after 24 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 0.35 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4619408 | F | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 40 uM measured after 24 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 2.32 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4619409 | F | Induction of apoptosis in human A549 cells assessed as necrotic cells at 40 uM measured after 24 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 0.37 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4619410 | F | Induction of apoptosis in human A549 cells assessed as live cells at 40 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 95.5 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4619411 | F | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 40 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 0.40 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4619412 | F | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 40 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 3.63 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4619413 | F | Induction of apoptosis in human A549 cells assessed as necrotic cells at 40 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based FACSClibur flow cytometry analysis (Rvb = 0.49 %) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4619414 | F | Induction of apoptosis in human A549 cells assessed as induction of caspase-3 activation at 40 uM using Ac-DEVD-pNA as substrate preincubated for 24 hrs followed by substrate addition and measured after 2 hrs by microplate reader assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4619415 | B | Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated for 90 mins by fluorescence assay | Homo sapiens | 5 | single protein format | Scientific Literature |
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