Drug uptake in tumor of Harlan Foxn1 nude mouse xenografted with rat RIE cells transfected with KIF5B/RET at 3 to 30 mg/kg, po administered bid for 8 days by LC-MS/MS analysis
Drug uptake in plasma of Harlan Foxn1 nude mouse xenografted with rat RIE cells transfected with KIF5B/RET at 3 to 30 mg/kg, po administered bid for 8 days by LC-MS/MS analysis
Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luciferase reporter gene assay
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luciferase reporter gene assay
Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter Glo assay
Antitumor activity against rat RIE cells transfected with KIF5B/RET xenografted in Harlan Foxn1 nude mouse assessed as tumor regression at 30 mg/kg, po administered bid for 8 days