| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4621227 | B | Inhibition of Pseudomonas aeruginosa PA14 LasB using 2-Aminobenzoyl-AlaGly-Leu-Ala-4-Nitrobenzylamide as fluorogenic substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by FRET assay | Pseudomonas aeruginosa PA14 | 32 | single protein format | Scientific Literature | ||
| 2. | ALA4621228 | B | Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay | Hathewaya histolytica | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4621229 | B | Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells at 1 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control | Hathewaya histolytica | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4621230 | B | Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control | Hathewaya histolytica | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4621231 | B | Inhibition of Clostridium histolyticum ColG collagenase unit at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control | Hathewaya histolytica | 2 | single protein format | Scientific Literature | ||
| 6. | ALA4621232 | B | Inhibition of Clostridium tetani ColT peptidase domain expressed in Escherichia coli BL21(DE3) cells at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control | Clostridium tetani | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4621233 | B | Inhibition of Bacillus cereus Q1 ColQ1 collagenase unit at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control | Bacillus cereus | 2 | assay format | Scientific Literature | ||
| 8. | ALA4621234 | A | Inhibition of recombinant human MMP1 catalytic domain (106 to 261 residues) expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 9. | ALA4621235 | A | Inhibition of recombinant human His-tagged MMP2 expressed in CHO cells at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4621236 | A | Inhibition of recombinant human His-tagged MMP3 catalytic domain (Pro19 to Glu271 residues) expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 11. | ALA4621237 | A | Inhibition of recombinant human MMP7 expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 12. | ALA4621238 | A | Inhibition of recombinant human full-length MMP8 at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA4621239 | A | Inhibition of recombinant human His-tagged MMP14 expressed in Escherichia coli at 100 uM using 5-FAM/QXL520-labelled FRET peptide as substrate preincubated for 10 to 15 mins followed by substrate addition and measured every minute for 1 hr by FRET assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 14. | ALA4621240 | A | Inhibition of recombinant human HDAC3 expressed in insect cells using R-H-K-K(Ac)-AFC as substrate by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4621241 | A | Inhibition of recombinant human HDAC8 expressed in baculovirus infected insect cells using R-H-K(Ac)-K(Ac)-AFC as substrate by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4621242 | A | Inhibition of recombinant human TACE1 expressed in insect cells using FRET-tagged substrate by FRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4621243 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4621244 | A | Cytotoxicity against HEK293 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4621245 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4621246 | A | Toxicity in 1 day post-fertilized zebrafish embryo AB measured up to 120 hrs post-fertilization by microscopic analysis | Danio rerio | 3 | assay format | Scientific Literature |
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