# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4605225 | B | Displacement of [3H]N-methylscopolamine from human muscarinic M1 receptor transiently expressed in HEK293T cell membranes incubated for 1 hr by scintillation counting method | Homo sapiens | 31 | ALA4602697 | cell-based format | Scientific Literature | |
2. | ALA4605226 | A | Displacement of [3H]N-methylscopolamine from human muscarinic M2 receptor transiently expressed in HEK293T cell membranes incubated for 1 hr by scintillation counting method | Homo sapiens | 31 | ALA4602697 | cell-based format | Scientific Literature | |
3. | ALA4605227 | B | Displacement of [3H]N-methylscopolamine from human muscarinic M3 receptor transiently expressed in HEK293T cell membranes incubated for 1 hr by scintillation counting method | Homo sapiens | 31 | ALA4602697 | cell-based format | Scientific Literature | |
4. | ALA4605228 | B | Selectivity ratio of Ki for human muscarinic M1 receptor transiently expressed in HEK293T cell membranes to Ki for human muscarinic M3 receptor transiently expressed in HEK293T cell membranes | Homo sapiens | 25 | ALA4602697 | cell-based format | Scientific Literature | |
5. | ALA4605229 | B | Selectivity ratio of Ki for human muscarinic M2 receptor transiently expressed in HEK293T cell membranes to Ki for human muscarinic M3 receptor transiently expressed in HEK293T cell membranes | Homo sapiens | 31 | ALA4602697 | cell-based format | Scientific Literature | |
6. | ALA4605230 | F | Agonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as increase in IP1 accumulation incubated for 90 min by TR-HTRF assay | Homo sapiens | 4 | ALA4602697 | cell-based format | Scientific Literature | |
7. | ALA4605231 | F | Agonist activity at human muscarinic M3 receptor expressed in HEK293 cells assessed as increase in IP1 accumulation incubated for 90 min by TR-HTRF assay relative to quinpirole | Homo sapiens | 9 | ALA4602697 | cell-based format | Scientific Literature | |
8. | ALA4605232 | F | Antagonist activity at human muscarinic M3 receptor expressed in HEK293 assessed as inhibition of carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition and measured after 90 mins by TR-HTRF assay | Homo sapiens | 8 | ALA4602697 | cell-based format | Scientific Literature | |
9. | ALA4605233 | F | Antagonist activity at human muscarinic M3 receptor expressed in HEK293 assessed as inhibition of carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition and measured after 90 mins by TR-HTRF assay relative to quinpirole | Homo sapiens | 8 | ALA4602697 | cell-based format | Scientific Literature | |
10. | ALA4605235 | B | Antagonist activity at muscarinic M3 receptor (unknown origin) expressed in HEK293 cells coexpressing EA tagged beta-arrestin2 assessed as inhibition of carbachol-induced beta-arrestin2 recruitment preincubated for 30 mins followed by carbachol addition and measured after 90 mins by PathHunter assay | Homo sapiens | 8 | ALA4602697 | cell-based format | Scientific Literature | |
11. | ALA4605236 | B | Agonist activity at muscarinic M3 receptor (unknown origin) expressed in HEK293 cells coexpressing EA tagged beta-arrestin2 assessed as beta-arrestin2 recruitment incubated for 90 mins by PathHunter assay relative to quinpirole | Homo sapiens | 9 | ALA4602697 | cell-based format | Scientific Literature | |
12. | ALA4605237 | B | Antagonist activity at muscarinic M3 receptor (unknown origin) expressed in HEK293 cells coexpressing EA tagged beta-arrestin2 assessed as inhibition of carbachol-induced beta-arrestin2 recruitment preincubated for 30 mins followed by carbachol addition and measured after 90 mins by PathHunter assay relative to quinpirole | Homo sapiens | 8 | ALA4602697 | cell-based format | Scientific Literature | |
13. | ALA4605238 | A | Permeability across apical to basolateral side in human Caco2 cells expressing Pgp at 1 uM measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 2 | ALA4602697 | cell-based format | Scientific Literature | |
14. | ALA4605239 | A | Permeability across basolateral to apical side in human Caco2 cells coexpressing Pgp at 1 uM measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 2 | ALA4602697 | cell-based format | Scientific Literature | |
15. | ALA4605240 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in human Caco2 cells coexpressing Pgp at 1 uM measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 2 | ALA4602697 | cell-based format | Scientific Literature | |
16. | ALA4605241 | A | Permeability across apical to basolateral side in human Caco2 cells coexpressing Pgp at 10 uM measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 2 | ALA4602697 | cell-based format | Scientific Literature | |
17. | ALA4605242 | A | Permeability across basolateral to apical side in human Caco2 cells coexpressing Pgp at 10 uM measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 2 | ALA4602697 | cell-based format | Scientific Literature | |
18. | ALA4605243 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in human Caco2 cells coexpressing Pgp at 10 uM measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 2 | ALA4602697 | cell-based format | Scientific Literature | |
19. | ALA4605244 | A | Permeability across basolateral to apical side in human Caco2 cells coexpressing Pgp at 5 uM in presence of P-gp inhibitor valspodar measured for 3 hrs by UPLC/MS analysis | Homo sapiens | 3 | ALA4602697 | cell-based format | Scientific Literature | |
20. | ALA4605248 | F | Ratio of EC50 for darifenacin to EC50 for test compound for antagonist activity at human muscarinic M3 receptor expressed in HEK293 assessed as inhibition of carbachol-induced IP1 accumulation preincubated for 30 mins followed by carbachol addition and measured after 90 mins by TR-HTRF assay | Homo sapiens | 6 | ALA4602697 | assay format | Scientific Literature |