| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4611266 | B | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay | Homo sapiens | 61 | ALA4610036 | cell-based format | Scientific Literature | |
| 2. | ALA4611267 | B | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay relative to control | Homo sapiens | 61 | ALA4610036 | cell-based format | Scientific Literature | |
| 3. | ALA4611268 | F | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay | Homo sapiens | 61 | ALA4610036 | cell-based format | Scientific Literature | |
| 4. | ALA4611269 | F | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay relative to control | Homo sapiens | 61 | ALA4610036 | cell-based format | Scientific Literature | |
| 5. | ALA4611273 | P | Ratio of solubility of compound in aqueous buffer at pH 5 to 7.4 to IC50 for Prolink-tagged human CXCR6 receptor by DiscoveRx cell based assay | 1 | ALA4610036 | cell-based format | Scientific Literature | ||
| 6. | ALA4611274 | A | Stability in mouse plasma | Mus musculus | 1 | ALA4610036 | cell-free format | Scientific Literature | |
| 7. | ALA4611275 | A | Stability in human plasma | Homo sapiens | 1 | ALA4610036 | cell-free format | Scientific Literature | |
| 8. | ALA4611276 | T | Toxicity in human liver microsomes | Homo sapiens | 1 | ALA4610036 | microsome format | Scientific Literature | |
| 9. | ALA4611277 | A | Drug metabolism in human liver microsomes incubated up to 1 hr | Homo sapiens | 1 | ALA4610036 | microsome format | Scientific Literature | |
| 10. | ALA4611278 | A | Drug metabolism in mouse liver microsomes incubated up to 1 hr | Mus musculus | 1 | ALA4610036 | microsome format | Scientific Literature | |
| 11. | ALA4611279 | A | Clearance in mouse at 5 mg/kg, iv | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 12. | ALA4611280 | A | Volume of distribution at steady state in mouse at 5 mg/kg, iv | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 13. | ALA4611281 | A | Half life in mouse at 5 mg/kg, iv | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 14. | ALA4611282 | A | Cmax in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 15. | ALA4611283 | A | Half life in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 16. | ALA4611284 | A | AUC in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 17. | ALA4611285 | T | Toxicity in human SKHEP1 cells assessed as effect on cell viability after 72 hrs | Homo sapiens | 1 | ALA4610036 | cell-based format | Scientific Literature | |
| 18. | ALA4611286 | B | Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay | Homo sapiens | 3 | ALA4610036 | cell-based format | Scientific Literature | |
| 19. | ALA4611287 | T | Toxicity in NOD/SCID mouse xenografted with human SKHEP1 cells assessed as animal death at 30 to 60 mg/kg, po administered on day 4 to day 30 post-tumor cell inoculation | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature | |
| 20. | ALA4611288 | T | Toxicity in NOD/SCID mouse xenografted with human SKHEP1 cells assessed as effect on behavior phenotypes at 30 to 60 mg/kg, po administered on day 4 to day 30 post-tumor cell inoculation | Mus musculus | 1 | ALA4610036 | organism-based format | Scientific Literature |
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