| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4630441 | B | Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 2. | ALA4630442 | F | Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 3. | ALA4630443 | A | Metabolic stability in rat hepatocytes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4630444 | A | Metabolic stability in human hepatocytes assessed as parent compound remaining at 1 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA4630445 | A | Clearance in rat at 0.5 mg/kg, iv | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 6. | ALA4630446 | A | Oral bioavailability in rat at 2 mg/kg | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 7. | ALA4630447 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 8. | ALA4630448 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac sodium salt as substrate incubated for 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 9. | ALA4630449 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate incubated for 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 10. | ALA4630450 | A | Inhibition of CYP2D6 in human liver microsomes using bufuralol hydrochloride salt as substrate incubated for 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 11. | ALA4630451 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam hydrochloride as substrate incubated for 20 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 12. | ALA4630452 | A | Ratio of IC50 for time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam hydrochloride as substrate in presence of NADPH to IC50 for time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam hydrochloride as substrate absence of NADPH | Homo sapiens | 2 | microsome format | Scientific Literature | ||
| 13. | ALA4630453 | B | Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4630454 | A | Clearance in mouse at 0.5 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4630455 | A | Volume of distribution at steady state in mouse at 0.5 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4630456 | A | Half life in mouse at 0.5 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4630457 | A | AUC (0 to last) in mouse at 2 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4630458 | A | Oral bioavailability in mouse at 2 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4630459 | B | Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4630460 | B | Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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