# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4650107 | B | Thermal Shift Assay. Domain start/stop: M626-G740 | Homo sapiens | 1,014 | ALA4649998 | single protein format | EUbOPEN Chemogenomic Library | |
2. | ALA4725212 | T | Incucyte cell viability with HEK293T | Homo sapiens | 1,713 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
3. | ALA4725213 | T | Incucyte cell viability with human fibroblast | Homo sapiens | 1,718 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
4. | ALA4725214 | T | Incucyte cell viability with U2OS | Homo sapiens | 1,712 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
5. | ALA4836547 | A | Oral bioavailability in male Wistar Han rat measured up to 7 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4834464 | organism-based format | Scientific Literature | |
6. | ALA4836548 | A | Blood clearance in male Wistar Han rat measured up to 7 hrs by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4834464 | assay format | Scientific Literature | |
7. | ALA4836549 | B | Binding affinity to 6His-Thr-BRD4 (1 to 477 residues) BD2 domain Y390A mutant (unknown origin) incubated for 30 mins by TR-FRET assay | Homo sapiens | 49 | ALA4834464 | assay format | Scientific Literature | |
8. | ALA4836550 | B | Binding affinity to 6His-Thr-BRD4 (1 to 477 residues) BD1 domain Y97A mutant (unknown origin) incubated for 30 mins by TR-FRET assay | Homo sapiens | 49 | ALA4834464 | assay format | Scientific Literature | |
9. | ALA4836551 | B | Selectivity for 6His-Thr-BRD4 (1 to 477 residues) BD2 domain Y390A mutant (unknown origin) over 6His-Thr-BRD4 (1 to 477 residues) BD1 domain Y97A mutant (unknown origin) | Homo sapiens | 49 | ALA4834464 | assay format | Scientific Literature | |
10. | ALA4836552 | P | Kinetic solubility of compound in DMSO using the charged aerosol detector (CAD) analysis | 31 | ALA4834464 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4836553 | A | Permeability of compound by AMP assay | 49 | ALA4834464 | assay format | Scientific Literature | ||
12. | ALA4836554 | P | Solubility of the compound in FaSSIF at pH 6.5 incubated for 16 hrs by HPLC gradient analysis | 27 | ALA4834464 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4836556 | P | Distribution coefficient, logD of the compound by chromatography | 49 | ALA4834464 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4836559 | A | Intrinsic clearance in human hepatocytes measured per gram of tissue incubated for 120 mins by LC-MS/MS method | Homo sapiens | 13 | ALA4834464 | cell-based format | Scientific Literature | |
15. | ALA4836630 | B | Inhibition of 6His-Thr-BRD4 (1 to 477 residues) BD2 domain Y390A mutant (unknown origin) incubated for 30 mins by TR-FRET assay | Homo sapiens | 40 | ALA4834466 | single protein format | Scientific Literature | |
16. | ALA4836631 | B | Inhibition of 6His-Thr-BRD4 (1 to 477 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assay | Homo sapiens | 40 | ALA4834466 | single protein format | Scientific Literature | |
17. | ALA4836632 | P | Lipophilicity, logD of compound at pH 7.4 | 40 | ALA4834466 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA4836633 | P | Solubility by CLND assay | 40 | ALA4834466 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4836634 | P | Solubility of the compound in pH 6.5 FaSSIF at 2.5 mg/ml measured after 16 hrs by HPLC analysis | 10 | ALA4834466 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4836635 | A | Metabolic stability in rat Hepatocyte assessed as intrinsic clearance at 0.5 uM incubated for 60 mins by LC-MS/MS analysis | Rattus norvegicus | 23 | ALA4834466 | tissue-based format | Scientific Literature |