| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4627171 | T | Cardiotoxicity in human iPSC derived cardiomyocytes assessed as reduction in beating rate at 1 nM | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA4627172 | T | Cardiotoxicity in human iPSC derived cardiomyocytes assessed as reduction in beating rate at 10 nM | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA4767214 | T | Cardiotoxicity in human iPSC derived cardiomyocytes assessed as reduction in beating rate at 1 nM measured over 2 hrs by multi-electrode array relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA4767215 | T | Cardiotoxicity in human iPSC derived cardiomyocytes assessed as reduction in beating rate at 10 nM measured over 2 hrs by multi-electrode array relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA4767216 | B | Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analysis | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 6. | ALA4767217 | B | Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analysis relative to control | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 7. | ALA4767218 | F | Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of cAMP accumulation incubated for 10 mins by HTRF assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 8. | ALA4767219 | F | Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of cAMP accumulation incubated for 10 mins by HTRF assay relative to control | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 9. | ALA4767220 | F | Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 10. | ALA4767221 | F | Agonist activity at human recombinant S1P1 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay relative to control | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 11. | ALA4767222 | B | Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated for 50 mins by fluorescence based confocal laser scanning microscopic analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4767223 | B | Agonist activity at human recombinant C-terminal GFP-fused S1P1 expressed in CHO cells assessed as induction of receptor internalization incubated for 50 mins by fluorescence based confocal laser scanning microscopic analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4767224 | B | Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate reader analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4767225 | B | Agonist activity at human recombinant S1P1 expressed in CHO cells assessed as stimulation of ERK phosphorylation incubated for 7 mins by microplate reader analysis relative to S1P | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4767226 | A | Agonist activity at human recombinant S1P3 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 16. | ALA4767227 | F | Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 17. | ALA4767228 | F | Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay | Homo sapiens | 3 | cell membrane format | Scientific Literature | ||
| 18. | ALA4767229 | F | Antimigratory activity against human T cells assessed as inhibition of S1P-induced T cell migration preincubated for 10 mins followed by addition of S1P measured after 120 mins by calcein-AM dye based fluorescence analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4767242 | A | Tmax in Sprague-Dawley rat at 1 mg/kg, po or 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA4767243 | A | Tmax in Beagle dog at 0.3 mg/kg, po or 1 mg/kg, iv | Canis lupus familiaris | 2 | organism-based format | Scientific Literature |
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