#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4613059	Binding	Inhibition of EED ( 1 to 441 residues) (unknown origin) pre-incubated for 15 mins before biotin-H3K27me3 (19 to 33 residues) addition and further incubated for 30 mins by AlphaScreen.based EED-H3K27me3 peptide competition binding assay	Homo sapiens	35	ALA4610126	single protein format	Scientific Literature
2.	ALA4613060	Functional	Growth inhibition of human KARPAS422 cells incubated for 7 days by WST8 assay	Homo sapiens	35	ALA4610126	cell-based format	Scientific Literature
3.	ALA4613061	Functional	Growth inhibition of human Pfeiffer cells incubated for 7 days by WST8 assay	Homo sapiens	19	ALA4610126	cell-based format	Scientific Literature
4.	ALA4613062	ADME	Plasma concentration in mouse at 25 mg/kg, po after 1 hr by LC-MS/MS analysis	Mus musculus	12	ALA4610126	organism-based format	Scientific Literature
5.	ALA4613063	ADME	Plasma concentration in mouse at 25 mg/kg, po after 3 hrs by LC-MS/MS analysis	Mus musculus	12	ALA4610126	organism-based format	Scientific Literature
6.	ALA4613064	ADME	Plasma concentration in mouse at 25 mg/kg, po after 6 hrs by LC-MS/MS analysis	Mus musculus	12	ALA4610126	organism-based format	Scientific Literature
7.	ALA4613065	Functional	Inhibition of EED in SCID mouse xenografted with human KARPAS422 cells assessed as reduction in H3K27me3 level in tumor at 100 mg/kg, po dosed as single administration measured after 24 hrs by Western blotting analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
8.	ALA4613066	Functional	Antitumor activity against human KARPAS422 cells xenografted in SCID mouse assessed as induction of tumor regression at 50 mg/kg, po dosed daily for 28 days relative to control	Homo sapiens	2	ALA4610126	organism-based format	Scientific Literature
9.	ALA4613067	Functional	Antitumor activity against human KARPAS422 cells xenografted in SCID mouse assessed as induction of tumor regression at 100 mg/kg, po dosed daily for 28 days relative to control	Homo sapiens	2	ALA4610126	organism-based format	Scientific Literature
10.	ALA4613068	Toxicity	Toxicity in SCID mouse xenografted with human KARPAS422 cells assessed as induction of body weight loss at 50 to 100 mg/kg, po dosed daily for 28 days	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
11.	ALA4613069	ADME	AUC (0 to t) in mouse at 2 mg/kg, iv by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
12.	ALA4613070	Functional	Antitumor activity against human KARPAS422 cells xenografted in SCID mouse assessed as reduction in tumor re-growth at 50 to 100 mg/kg, po dosed daily for 28 days followed by treatment cessation for 72 days relative to control	Homo sapiens	2	ALA4610126	organism-based format	Scientific Literature
13.	ALA4613071	ADME	Terminal half life in mouse at 10 mg/kg, po by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
14.	ALA4613072	ADME	Cmax in mouse at 10 mg/kg, po by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
15.	ALA4613073	ADME	AUC (0 to t) in mouse at 10 mg/kg, po by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
16.	ALA4613074	ADME	Plasma clearance in mouse at 2 mg/kg, iv by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
17.	ALA4613075	ADME	Volume of distribution at steady state in mouse at 2 mg/kg, iv by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
18.	ALA4613076	ADME	Oral bioavailability in mouse at 10 mg/kg by LC-MS/MS analysis	Mus musculus	2	ALA4610126	organism-based format	Scientific Literature
19.	ALA4613077	Binding	Potency index, ratio of IC50 for EED226 to IC50 for test compound for inhibition of EED ( 1 to 441 residues) (unknown origin) pre-incubated for 15 mins before biotin-H3K27me3 (19 to 33 residues) addition and further incubated for 30 mins by AlphaScreen.based EED-H3K27me3 peptide competition binding assay	Homo sapiens	1	ALA4610126	single protein format	Scientific Literature
20.	ALA4613078	Functional	Potency index, ratio of IC50 for EED226 to IC50 for test compound for growth inhibition of human KARPAS422 cells incubated for 7 days by WST8 assay	Homo sapiens	1	ALA4610126	cell-based format	Scientific Literature