| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4615294 | F | In-vivo activation of RXRalpha in BALB/c mouse xenografted with human KM12C cells assessed as induction of beta-catenin protein degradation at 100 mg/kg, ig dosed daily for 15 days by Western blot analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA4615295 | F | Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 3. | ALA4615296 | B | Activation of RXRalpha LBD (unknown origin) expressed in human KM12C cells at 50 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4615297 | B | Activation of RXRalpha R371S mutant LBD (unknown origin) expressed in human KM12C cells at 50 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4615298 | F | Inhibition of cell proliferation of human HCT116 cells incubated for 15 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4615299 | F | Inhibition of cell proliferation of human SW620 cells incubated for 15 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4615300 | F | Inhibition of cell proliferation of human KM12C cells at 25 to 50 uM incubated for 15 hrs by EdU assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4615301 | F | Inhibition of cell proliferation of human HCT116 cells at 30 to 60 uM incubated for 15 hrs by EdU assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4615302 | F | Inhibition of cell proliferation of human SW620 cells at 40 to 80 uM incubated for 15 hrs by EdU assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4615303 | B | Activation of RXRalpha in human KM12C cells assessed as increase in PCNA protein expression at 25 to 50 uM incubated for 15 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4615304 | B | Activation of RXRalpha in human HCT116 cells assessed as increase in PCNA protein expression at 30 to 60 uM incubated for 15 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4615305 | B | Activation of RXRalpha in human SW620 cells assessed as increase in PCNA protein expression at 40 to 80 uM incubated for 15 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4615306 | B | Activation of RXRalpha in human KM12C cells assessed as increase transactivational activity on RXRE at 25 to 50 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4615307 | B | Activation of RXRalpha in human HCT116 cells assessed as increase transactivational activity on RXRE at 30 to 60 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4615308 | B | Activation of RXRalpha in human SW620 cells assessed as increase transactivational activity on RXRE at 40 to 80 uM incubated for 15 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4615309 | B | Binding affinity to His-tagged RXRalpha LBD (unknown origin) expressed in Escherichia coli strain BL21 (DE3) at 200 uM by STD-NMR spectroscopy | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA4615310 | B | Binding affinity to His-tagged RXRalpha LBD (unknown origin) expressed in Escherichia coli strain BL21 (DE3) by fluorescence quenching analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 18. | ALA4615311 | B | Induction of conformational changes in His-tagged RXRalpha LBD (unknown origin) expressed in Escherichia coli strain BL21 (DE3) at 5 uM by circular dichroism spectroscopic assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 19. | ALA4615312 | B | Activation of RXRalpha in human KM12C cells assessed as inhibition of Wnt/beta-catenin-dependent transcriptional activity at 25 to 50 uM incubated for 15 hrs by TOP/FOP luciferase assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4615313 | B | Activation of RXRalpha in human HCT116 cells assessed as inhibition of Wnt/beta-catenin-dependent transcriptional activity at 30 to 60 uM incubated for 15 hrs by TOP/FOP luciferase assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
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