# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4611051 | Binding | Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion incubated for 18 hrs by ELISA | Mus musculus | 14 | ALA4610021 | cell-based format | Scientific Literature | |
2. | ALA4611052 | Binding | Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion incubated for 18 hrs by ELISA relative to 1V209 | Mus musculus | 14 | ALA4610021 | cell-based format | Scientific Literature | |
3. | ALA4611053 | Binding | Agonist activity at TLR7 in mouse BMDC cells assessed as immunostimulatory activity by measuring increase in IL6 secretion incubated for 18 hrs by ELISA | Mus musculus | 14 | ALA4610021 | cell-based format | Scientific Literature | |
4. | ALA4611054 | Binding | Agonist activity at TLR7 in mouse BMDC cells assessed as immunostimulatory activity by measuring increase in IL6 secretion incubated for 18 hrs by ELISA relative to 1V209 | Mus musculus | 14 | ALA4610021 | cell-based format | Scientific Literature | |
5. | ALA4611056 | Binding | Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion incubated for 6 hrs in absence of actin polymerization inhibitor cytochalasin D by ELISA | Mus musculus | 4 | ALA4610021 | cell-based format | Scientific Literature | |
6. | ALA4611057 | Binding | Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion preincubated with actin polymerization inhibitor cytochalasin D followed by incubation with compound for 6 hrs by ELISA | Mus musculus | 4 | ALA4610021 | cell-based format | Scientific Literature | |
7. | ALA4767142 | Functional | Adjuvanted-antitumor vaccine activity in C57BL/6 mouse bone marrow derived cells assessed as induction of IL-12 production at 10^-4 to 10^1 ug/ml incubated for 48 hrs by ELISA | Mus musculus | 5 | ALA4765240 | cell-based format | Scientific Literature | |
8. | ALA4767143 | Functional | Adjuvanted-antitumor vaccine activity in C57BL/6 mouse bone marrow derived cells assessed as induction of IL-6 production at 10^-4 to 10^1 ug/ml incubated for 48 hrs by ELISA | Mus musculus | 5 | ALA4765240 | cell-based format | Scientific Literature | |
9. | ALA4767149 | ADME | Cytotoxicity against OT2 mouse CD4-positive T cells xenografted in C57BL/6 mouse assessed as reduction in cell viability in splenocytes by flow cytometry analysis | Mus musculus | 3 | ALA4765240 | cell-based format | Scientific Literature |