| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4627760 | B | Agonist activity at TLR8 in human PBMC assessed as induction of myeloid dendritic cell maturation by measuring increase in CD80 level at 0.1 uM after 6 hrs by flow cytometry relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4627766 | B | Agonist activity at TLR8 in human PBMC assessed as induction of myeloid dendritic cell maturation by measuring HLA-DR level at 0.1 uM after 6 hrs by flow cytometry | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA4627768 | B | Agonist activity at TLR8 in human PBMC assessed as induction of myeloid dendritic cell maturation by measuring CD86 level at 0.1 uM after 6 hrs by flow cytometry | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA4627770 | B | Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 5. | ALA4627771 | B | Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 6. | ALA4627772 | B | Potency index, ratio of resiquimod EC50 to test compound EC50 for agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4627773 | B | Agonist activity at human TLR3 expressed in HEK293 cells by SEAP reporter gene assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4627774 | B | Agonist activity at human TLR9 expressed in HEK293 cells by SEAP reporter gene assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4627775 | B | Agonist activity at TLR7/TLR8 in human PBMC assessed as IFN alpha level | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 10. | ALA4627776 | B | Agonist activity at TLR7 in human PBMC assessed as IFNalpha stimulation at 10 uM | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 11. | ALA4627777 | B | Agonist activity at TLR8 in human PBMC assessed as TNFalpha level | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 12. | ALA4627778 | B | Agonist activity at TLR8 in human PBMC assessed as TNFalpha level at 10 uM | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 13. | ALA4627780 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring increase in MHC-1 level at 0.1 uM after 6 hrs by flow cytometry relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 14. | ALA4627781 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring increase in HLA-DR level at 0.1 uM after 6 hrs by flow cytometry relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 15. | ALA4627782 | B | Agonist activity at TLR7 in human PBMC assessed as induction of plasmacytoid dendritic cell maturation by measuring increase in CD86 level at 0.1 uM after 6 hrs by flow cytometry relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature |
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