| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4622176 | A | Fraction unbound in human plasma | Homo sapiens | 16 | cell-free format | Scientific Literature | ||
| 2. | ALA4622177 | A | Fraction unbound in mouse plasma | Mus musculus | 16 | cell-free format | Scientific Literature | ||
| 3. | ALA4622179 | B | Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abeta42 production after 24 hrs by Alphalisa assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA4622180 | B | Modulation of mouse gamma secretase assessed as reduction in Abeta42 production | Mus musculus | 13 | assay format | Scientific Literature | ||
| 5. | ALA4622184 | P | Octanol/water distribution co-efficient, log D of the compound at pH 7.4 | 20 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4622185 | P | Solubility of compound by lyophilisation solubility assay | 20 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA4622186 | A | Clearance in human hepatocytes assessed per million cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 8. | ALA4622187 | A | Clearance in mouse hepatocytes assessed per million cells | Mus musculus | 16 | cell-based format | Scientific Literature | ||
| 9. | ALA4622188 | B | Inhibition of human Pgp assessed as efflux ratio | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 10. | ALA4622189 | B | Inhibition of human ERG | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 11. | ALA4622190 | B | Inhibition of mouse Pgp assessed as efflux ratio | Mus musculus | 6 | assay format | Scientific Literature | ||
| 12. | ALA4622191 | A | Binding affinity to PIK4CB (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 13. | ALA4622192 | A | Glutathione reactivity of the compound assessed as GSH-adduct formation | 3 | assay format | Scientific Literature | |||
| 14. | ALA4622194 | A | Inhibition of human Notch1 expressed in HEK293 cells coexpressing luciferase reporter measured after 20 hrs by steady-glo chemiluminescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4622195 | A | Fraction unbound in rat plasma | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 16. | ALA4622196 | A | Clearance in rat hepatocytes assessed per million cell | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4622197 | A | Dose normalized AUC (infinity) in rat at 2 mg/kg, po via gavage measured over 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4622198 | A | Clearance in rat at 1 mg/kg, iv bolus measured over 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4622199 | A | Terminal half life in rat at 1 mg/kg, iv bolus measured over 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4622200 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv bolus measured over 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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