| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4626968 | B | Selectivity ratio, difference between pKD for N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escherichia coli to pKD for BRD4 BD2 (333 to 460 residues) (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA4626969 | B | Binding affinity to BRD4 BD2 (333 to 460 residues) (unknown origin) by surface plasmon resonance method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA4626970 | B | Displacement of bromosporine-tracer from BRD4 (unknown origin) expressed in HEK293 cells by NanoBRET NanoGlo substrate based NanoBRET assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4626971 | F | Antiinflammatory activity in human PBMC assessed as reduction in LPS-induced IL-6 production incubated for 18 to 24 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4626972 | F | Antiinflammatory activity in human PBMC assessed as reduction in LPS-induced MCP1 production incubated for 18 to 24 hrs by mesoscale assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4626973 | F | Antiinflammatory activity in human whole blood assessed as reduction in LPS-induced IL-6 production preincubated for 30 mins followed by LPS challenge and measured after overnight incubation by mesoscale assay | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 7. | ALA4626974 | F | Growth inhibition of human MV4-11 cells incubated for 72 hrs by Cell-titre glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4626975 | F | Antiinflammatory activity in human whole blood assessed as reduction in LPS-induced MCP1 production preincubated for 30 mins followed by LPS challenge and measured after overnight incubation by mesoscale assay | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 9. | ALA4626976 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 10. | ALA4626977 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 11. | ALA4626978 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD2 (1 to 473 residues)/BD1 Y113A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 12. | ALA4626979 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/BD2 Y309A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 13. | ALA4626980 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 14. | ALA4626981 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 15. | ALA4626982 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/BD2 Y386A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 16. | ALA4626992 | B | Displacement of Alexa Fluor 647 labelled I-BET762 from N-terminal His6-tagged human BRDT BD2 (1 to 397 residues)/BD1 Y66A mutant expressed in Escherichia coli after 1 hr by TR-FRET assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 17. | ALA4626993 | B | Selectivity index, difference between pIC50 for N-terminal His6-tagged human BRD2 BD1 (1 to 473 residues)/ BD2 Y386A mutant expressed in Escherichia coli to pIC50 for N-terminal His6-tagged human BRD2 BD2 (1 to 473 residues)/BD1 Y113A mutant expressed in Escherichia coli | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 18. | ALA4626994 | B | Selectivity index, difference between pIC50 for N-terminal His6-tagged human BRD3 BD1 (1 to 435 residues)/BD2 Y348A mutant expressed in Escherichia coli to pIC50 for N-terminal His6-tagged human BRD3 BD2 (1 to 435 residues)/BD1 Y73A mutant expressed in Escherichia coli | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 19. | ALA4626995 | B | Selectivity index, difference between pIC50 for N-terminal His6-tagged human BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant expressed in Escherichia coli to pIC50 for N-terminal His6-tagged human BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant expressed in Escherichia coli | Homo sapiens | 20 | assay format | Scientific Literature | ||
| 20. | ALA4626996 | B | Selectivity index, difference between pIC50 for N-terminal His6-tagged human BRDT BD1 (1 to 397 residues)/ BD2 Y309A mutant expressed in Escherichia coli to pIC50 for N-terminal His6-tagged human BRDT BD2 (1 to 397 residues)/BD1 Y66A mutant expressed in Escherichia coli | Homo sapiens | 3 | assay format | Scientific Literature |
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