# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4622176 | A | Fraction unbound in human plasma | Homo sapiens | 16 | cell-free format | Scientific Literature | ||
2. | ALA4622177 | A | Fraction unbound in mouse plasma | Mus musculus | 16 | cell-free format | Scientific Literature | ||
3. | ALA4622179 | B | Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abeta42 production after 24 hrs by Alphalisa assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
4. | ALA4622180 | B | Modulation of mouse gamma secretase assessed as reduction in Abeta42 production | Mus musculus | 13 | assay format | Scientific Literature | ||
5. | ALA4622181 | F | In vivo modulation of gamma secretase in APP-Swedish transgenic mouse assessed as reduction in Abeta42 production by measuring remaining Abeta42 level at 1 mg/kg, po measured after 4 hrs by ELISA or AlphaLISA assay relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
6. | ALA4622182 | F | In vivo modulation of gamma secretase in APP-Swedish transgenic mouse assessed as reduction in Abeta42 production by measuring remaining Abeta42 level at 3 mg/kg, po measured after 4 hrs by ELISA or AlphaLISA assay relative to control | Mus musculus | 4 | organism-based format | Scientific Literature | ||
7. | ALA4622183 | F | In vivo modulation of gamma secretase in APP-Swedish transgenic mouse assessed as reduction in Abeta42 production by measuring remaining Abeta42 level at 10 mg/kg, po measured after 4 hrs by ELISA or AlphaLISA assay relative to control | Mus musculus | 5 | organism-based format | Scientific Literature | ||
8. | ALA4622184 | P | Octanol/water distribution co-efficient, log D of the compound at pH 7.4 | 20 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA4622185 | P | Solubility of compound by lyophilisation solubility assay | 20 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA4622186 | A | Clearance in human hepatocytes assessed per million cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
11. | ALA4622187 | A | Clearance in mouse hepatocytes assessed per million cells | Mus musculus | 16 | cell-based format | Scientific Literature | ||
12. | ALA4622188 | B | Inhibition of human Pgp assessed as efflux ratio | Homo sapiens | 6 | single protein format | Scientific Literature | ||
13. | ALA4622189 | B | Inhibition of human ERG | Homo sapiens | 6 | single protein format | Scientific Literature | ||
14. | ALA4622190 | B | Inhibition of mouse Pgp assessed as efflux ratio | Mus musculus | 6 | assay format | Scientific Literature | ||
15. | ALA4622191 | A | Binding affinity to PIK4CB (unknown origin) | Homo sapiens | 10 | single protein format | Scientific Literature | ||
16. | ALA4622211 | A | Phototoxicity in human Keratinocytes in presence of UVA at 320 to 400 nm | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
17. | ALA4622213 | A | Phototoxicity in human Melanocytes in presence of UVA at 320 to 400 nm | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
18. | ALA4622215 | A | Ratio of IC50 for dark toxicity in human Keratinocytes to IC50 for phototoxicity in human Keratinocytes in presence of UVA at 320 to 400 nm | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
19. | ALA4622216 | A | Ratio of IC50 for dark toxicity in human Melanocytes to IC50 for phototoxicity in human Melanocytes in presence of UVA at 320 to 400 nm | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
20. | ALA4622219 | A | Covalent protein binding in human liver microsomes assessed per mg protein in presence of NADPH | Homo sapiens | 10 | microsome format | Scientific Literature |