# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4610689 | Functional | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization | Homo sapiens | 38 | ALA4610000 | cell-based format | Scientific Literature | |
2. | ALA4610690 | Functional | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization relative to acetylcholine | Homo sapiens | 36 | ALA4610000 | cell-based format | Scientific Literature | |
3. | ALA4610691 | Binding | Positive allosteric modulation of rat muscarinic M4 receptor | Rattus norvegicus | 16 | ALA4610000 | single protein format | Scientific Literature | |
4. | ALA4610692 | ADME | Intrinsic clearance in rat microsomes | Rattus norvegicus | 8 | ALA4610000 | microsome format | Scientific Literature | |
5. | ALA4610693 | ADME | Intrinsic clearance in human microsomes | Homo sapiens | 8 | ALA4610000 | microsome format | Scientific Literature | |
6. | ALA4610694 | ADME | Unbound fraction in rat plasma | Rattus norvegicus | 8 | ALA4610000 | cell-free format | Scientific Literature | |
7. | ALA4610695 | ADME | Unbound fraction in human plasma | Homo sapiens | 8 | ALA4610000 | cell-free format | Scientific Literature | |
8. | ALA4610696 | ADME | Unbound fraction in rat brain | Rattus norvegicus | 8 | ALA4610000 | tissue-based format | Scientific Literature | |
9. | ALA4610697 | ADME | Brain to plasma permeability coefficient, Kp of the compound in Sprague-Dawley rat at 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 8 | ALA4610000 | organism-based format | Scientific Literature | |
10. | ALA4610698 | ADME | Unbound brain-to-plasma concentration ratio in Sprague-Dawley rat at 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 8 | ALA4610000 | organism-based format | Scientific Literature |