# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4612962 | Binding | Inhibition of recombinant human N-terminal His6-tagged DCLK1 (G351 to H689 residues) expressed in Escherichia coli BL21 DE3 using 5-FAM-KKLRRTLSVA-COOH as substrate measured after 2 hrs by mobility shift assay | Homo sapiens | 38 | ALA4610122 | assay format | Scientific Literature | |
2. | ALA4612964 | Binding | Inhibition of ERK5 in human HeLa cells assessed as reduction in EGF-induced ERK5 autophosphorylation pretreated for 1 hr followed by EGF stimulation and measured after 17 mins by 32p kinase assay | Homo sapiens | 16 | ALA4610122 | cell-based format | Scientific Literature | |
3. | ALA4612965 | Binding | Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substrate measured after 1 hr by Alexa fluor-647 ADP tracer-based ADAPTA assay | Homo sapiens | 36 | ALA4610122 | assay format | Scientific Literature | |
4. | ALA4612966 | Binding | Inhibition of BRD4 bromodomain 1 (unknown origin) by AlphaScreen displacement assay | Homo sapiens | 13 | ALA4610122 | single protein format | Scientific Literature | |
5. | ALA4612967 | Functional | Cytotoxicity against human Panc286 cell organoids assessed as reduction in cell viability up to 1 uM measured after 4 days | Homo sapiens | 1 | ALA4610122 | assay format | Scientific Literature | |
6. | ALA4612968 | Functional | Cytotoxicity against human Panc281 cell organoids assessed as reduction in cell viability up to 1 uM measured after 4 days | Homo sapiens | 1 | ALA4610122 | assay format | Scientific Literature | |
7. | ALA4612969 | Functional | Cytotoxicity against human Panc286 cell organoids assessed as reduction in cell viability at 1 uM measured after 12 days relative to control | Homo sapiens | 1 | ALA4610122 | assay format | Scientific Literature | |
8. | ALA4612970 | Functional | Cytotoxicity against human Panc281 cell organoids assessed as reduction in cell viability at 1 uM measured after 12 days relative to control | Homo sapiens | 1 | ALA4610122 | assay format | Scientific Literature | |
9. | ALA4612971 | ADME | Half life in mouse | Mus musculus | 1 | ALA4610122 | organism-based format | Scientific Literature | |
10. | ALA4612972 | ADME | AUC in mouse | Mus musculus | 1 | ALA4610122 | organism-based format | Scientific Literature | |
11. | ALA4612973 | ADME | Clearance in mouse | Mus musculus | 1 | ALA4610122 | organism-based format | Scientific Literature | |
12. | ALA4650107 | Binding | Thermal Shift Assay. Domain start/stop: M626-G740 | Homo sapiens | 1,014 | ALA4649998 | single protein format | EUbOPEN Chemogenomic Library | |
13. | ALA4689845 | Toxicity | Multiplex assay against human fibroblast | Homo sapiens | 458 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
14. | ALA4689846 | Toxicity | Multiplex assay against HEK293T | Homo sapiens | 458 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
15. | ALA4689853 | Toxicity | Multiplex assay against U2OS | Homo sapiens | 458 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
16. | ALA4725212 | Toxicity | Incucyte cell viability with HEK293T | Homo sapiens | 1,713 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
17. | ALA4725213 | Toxicity | Incucyte cell viability with human fibroblast | Homo sapiens | 1,718 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
18. | ALA4725214 | Toxicity | Incucyte cell viability with U2OS | Homo sapiens | 1,712 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
19. | ALA5060015 | Binding | Thermal Shift Assay. Domain: start/stop: S229-K512 | Homo sapiens | 1,499 | ALA5060014 | single protein format | EUbOPEN Chemogenomic Library | |
20. | ALA5060944 | Binding | Thermal Shift Assay. Domain: start/stop: N44-E168 | Homo sapiens | 1,502 | ALA5060014 | single protein format | EUbOPEN Chemogenomic Library |