| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4620360 | F | Osteo-blastogenic activity in mouse calvarial osteoblast assessed as upregulation of BMP2 mRNA expression at 1 pM to 100 pM measured after 48 hrs by qPCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4620363 | B | Induction of ESR2-mediated osteoblast differentiation in mouse calvarial osteoblast assessed as increase in ALP activity at 1 pM measured after 48 hrs by spectrophotometric analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4620364 | F | Upregulation of ALP mRNA expression in mouse calvarial osteoblast at 1 pM to 100 pM measured after 24 to 48 hrs by qPCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4620365 | F | Osteo-blastogenic activity in mouse calvarial osteoblast assessed as upregulation of Runx2 mRNA expression at 1 pM to 100 pM measured after 48 hrs by qPCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4620366 | B | Induction of ESR2-mediated osteoblast differentiation in mouse calvarial osteoblast assessed as formation of mineralized nodule at 1 to 10 uM measured after 21 days by alizarin red staining based assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4620367 | F | Anti-osteoporosis activity in ovariectomized BALB/c mouse assessed as increase in femur bone volume density at 1 to 5 mg/kg, po via gavage administered for 1 month by microCT imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4620368 | F | Anti-osteoporosis activity in ovariectomized BALB/c mouse assessed as increase in trabecular number in femur bone at 1 to 5 mg/kg, po via gavage administered for 1 month by microCT imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4620369 | F | Anti-osteoporosis activity in ovariectomized BALB/c mouse assessed as increase in trabecular thickness in femur bone at 1 to 5 mg/kg, po via gavage administered for 1 month by microCT imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4620370 | F | Anti-osteoporosis activity in ovariectomized BALB/c mouse assessed as reduction in trabecular spacing in femur bone at 1 to 5 mg/kg, po via gavage administered for 1 month by microCT imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4620371 | F | Anti-osteoporosis activity in ovariectomized BALB/c mouse assessed as reduction in trabecular pattern factor in femur bone at 1 to 5 mg/kg, po via gavage administered for 1 month by microCT imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4620377 | F | Anti-osteoporosis activity in ovariectomized BALB/c mouse at 5 mg/kg, po via gavage administered for 1 month by microCT imaging analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4620378 | F | Upregulation of ESR1 protein level in mouse calvarial osteoblast at 1 to 100 pM measured after 48 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4620379 | F | Upregulation of ESR2 protein level in mouse calvarial osteoblast at 1 to 100 pM measured after 48 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4620380 | F | Cytotoxicity against human MCF7 cells assessed as cell growth inhibition at 30 ug/ml by MTT assay relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 15. | ALA4620381 | A | Cytotoxicity against peritoneal macrophage cells (unknown origin) at 5 to 20 uM by MTT assay | Not specified | 1 | cell-based format | Scientific Literature |
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