| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4623752 | B | Positive allosteric modulation of muscarinic acetylcholine receptor M3 in Sprague-Dawley rat urinary bladder assessed as increase in 8 Hz electrical field stimulation-induced bladder contraction by measuring tension of isolated bladder contraction at 1 uM (Rvb = 2.21 +/- 0.26 g) | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 2. | ALA4623753 | F | Positive allosteric modulation of recombinant human muscarinic acetylcholine receptor M1 expressed in CHOK1 cells assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4623754 | F | Positive allosteric modulation of recombinant human muscarinic acetylcholine receptor M3 expressed in CHOK1 cells assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 4. | ALA4623755 | F | Positive allosteric modulation of recombinant rat muscarinic acetylcholine receptor M1 expressed in CHOK1 cells assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4623756 | F | Positive allosteric modulation of recombinant human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells coexpressing G-alpha16 assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM based FLIPR assay relative to carbachol | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4623757 | F | Positive allosteric modulation of recombinant rat muscarinic acetylcholine receptor M2 expressed in CHOK1 cells coexpressing G-alpha16 assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4623758 | F | Positive allosteric modulation of recombinant rat muscarinic acetylcholine receptor M3 expressed in CHOK1 cells assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4623759 | F | Positive allosteric modulation of recombinant human muscarinic acetylcholine receptor M4 expressed in CHOK1 cells coexpressing G-alpha16 assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4623760 | F | Positive allosteric modulation of recombinant rat muscarinic acetylcholine receptor M4 expressed in CHOK1 cells coexpressing G-alpha16 assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4623761 | F | Positive allosteric modulation of recombinant human muscarinic acetylcholine receptor M5 expressed in CHOK1 cells assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4623762 | F | Positive allosteric modulation of recombinant rat muscarinic acetylcholine receptor M5 expressed in CHOK1 cells assessed as increase in carbachol-induced intracellular calcium flux at 10 uM preincubated for 5 mins followed by carbachol addition by Fluo4-AM dye based FLIPR assay relative to carbachol | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4623763 | A | Agonist activity at recombinant human c-Mpl receptor transfected in BA/F3 cells assessed as increase in cell proliferation by cell counting analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 13. | ALA4623764 | B | Positive allosteric modulation of muscarinic acetylcholine receptor M3 in Sprague-Dawley rat urinary bladder assessed as increase in 8 Hz electrical field stimulation-induced bladder contraction | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4623765 | A | Cmax in Crl:CD(SD) rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4623766 | A | Tmax in Crl:CD(SD) rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4623767 | A | AUCinfinity in Crl:CD(SD) rat at 0.3 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4623768 | A | AUCinfinity in Crl:CD(SD) rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4623769 | A | Half life in Crl:CD(SD) rat at 0.3 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4623770 | A | Half life in Crl:CD(SD) rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4623771 | A | Total clearance in Crl:CD(SD) rat at 0.3 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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