# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4619594 | B | Protac activity at Cereblon/BCR/ABL in human K562 cells assessed as induction of BCR-ABL degradation incubated for 32 to 48 hrs by Western blot analysis | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
2. | ALA4619595 | F | Antiproliferative activity against human K562 cells incubated for 3 days by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
3. | ALA4619596 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant protein levels at 3 to 30000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4619597 | A | Antiproliferative activity against wild type mouse BA/F3 cells incubated for 3 days by CCK8 assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
5. | ALA4619598 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant driven cell viability incubated for 3 days by CCK8 assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
6. | ALA4619599 | B | Protac activity at Cereblon/BCR/ABL E255K mutant (unknown origin) expressed in human HeLa cells cells assessed as reduction in BCR-ABL E255K mutant protein levels at 10 to 10000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4619600 | B | Protac activity at Cereblon/BCR/ABL H396R mutant (unknown origin) expressed in human HeLa cells cells assessed as reduction in BCR-ABL H396R mutant protein levels at 10 to 10000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4619601 | B | Protac activity at Cereblon/BCR/ABL V468F mutant (unknown origin) expressed in human HeLa cells cells assessed as reduction in BCR-ABL V468F mutant protein levels at 10 to 10000 nM incubated for 32 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4619604 | A | Antiproliferative activity against rat H9C2 cells incubated for 3 days by CCK8 assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
10. | ALA4619605 | A | Antiproliferative activity against human HUVEC incubated for 3 days by CCK8 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4619606 | A | Inhibition of human ABL T315I mutant using EAIYAAPFAKKK substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA4619607 | A | Inhibition of human LYN using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
13. | ALA4619608 | A | Inhibition of human c-SRC using poly(Glu,Tyr)4:1 substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
14. | ALA4619609 | A | Inhibition of human VEGFR2 using MBP substrate and [gamma-33P]-ATP incubated for 40 mins by scintillation counting method | Homo sapiens | 2 | single protein format | Scientific Literature | ||
15. | ALA4619610 | T | Toxicity in HUVEC assessed as inhibition of tube formation at 1 uM incubated for 20 hrs by optical microscopy based matrigel-based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4619612 | B | Protac activity at Cereblon/BCR/ABL in human K562 cells assessed as synergistic antiproliferation effect by measuring combination index at 0.25 to 4 times alone antiproliferative EC50 ibn presence of hedgehog pathway inhibitor GDC-044 by Chou-Talalay method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4619613 | A | Protac activity at Cereblon/Flt3 in human K562 cells assessed as reduction in Flt3 protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4619614 | A | Protac activity at Cereblon/Src in human K562 cells assessed as reduction in Src protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4619615 | A | Protac activity at Cereblon/C-Kit in human K562 cells assessed as reduction in C-Kit protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4619616 | A | Protac activity at Cereblon/PDGFRalpha in human K562 cells assessed as reduction in PDGFRalpha protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |