| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4619009 | A | Clearance in BALB/c mouse at 3 mg/kg, iv administered as single bolus dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4619010 | A | Volume of distribution at steady state in BALB/c mouse at 3 mg/kg, iv administered as single bolus dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA4619014 | B | Inhibition of full length recombinant C-terminal His-tagged human acidic mammalian chitinase expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N-diacetylchitobioside hydrate as substrate incubated for 60 mins under shaking condition by microplate fluorometry analysis | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 4. | ALA4619015 | B | Inhibition of full length recombinant C-terminal His-taged human CHIT1 expressed in CHOK1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N',N''-diacetylchitotrioside as substrate incubated for 60 mins under shaking condition by microplate fluorometry analysis | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 5. | ALA4619016 | B | Selectivity index, ratio of IC50 for full length recombinant C-terminal His-taged human CHIT1 using 4-methylumbelliferyl-beta-D-N,N',N''-diacetylchitotrioside as substrate incubated for 60 mins under shaking condition by microplate fluorometry analysis to IC50 recombinant C-terminal His-tagged human acidic mammalian chitinase using 4-methylumbelliferyl-beta-D-N,N-diacetylchitobioside hydrate as substrate incubated for 60 mins under shaking condition by microplate fluorometry analysis | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 6. | ALA4619017 | B | Displacement of Tracer Red from human ERG by fluorescence polarization assay | Homo sapiens | 21 | single protein format | Scientific Literature | ||
| 7. | ALA4619019 | A | AUC (0 to infinity) in BALB/c mouse at 3 mg/kg, iv administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4619020 | A | Cmax in BALB/c mouse at 3 mg/kg, iv administered as single bolus dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4619021 | A | Half life in BALB/c mouse at 3 mg/kg, iv administered as single bolus dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4619022 | A | Mean residence time in BALB/c mouse at 3 mg/kg, iv administered as single bolus dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4619023 | A | AUC (0 to infinity) in BALB/c mouse at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4619024 | A | Cmax in BALB/c mouse at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4619025 | A | Tmax in BALB/c mouse at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4619026 | A | Half life in BALB/c mouse at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4619027 | A | Mean residence time in BALB/c mouse at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4619028 | A | Oral bioavailability in BALB/c mouse at 10 mg/kg administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4619029 | A | AUC(0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4619030 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature | ||
| 19. | ALA4619031 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4619032 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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