# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4623431 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of GSH measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
2. | ALA4623432 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at 50 and 100 uM after 24 hrs by MTT assay | Homo sapiens | 23 | ALA4622851 | cell-based format | Scientific Literature | |
3. | ALA4623433 | Functional | Cytotoxicity against human Jurkat cells assessed as reduction in cell viability at 50 and 100 uM after 24 hrs by MTT assay | Homo sapiens | 23 | ALA4622851 | cell-based format | Scientific Literature | |
4. | ALA4623434 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability after 24 hrs by MTT assay | Homo sapiens | 23 | ALA4622851 | cell-based format | Scientific Literature | |
5. | ALA4623435 | Functional | Cytotoxicity against human Jurkat cells assessed as reduction in cell viability after 24 hrs by MTT assay | Homo sapiens | 23 | ALA4622851 | cell-based format | Scientific Literature | |
6. | ALA4623436 | Functional | Induction of apoptosis in human SK-MEL-147 cells assessed as early apoptotic cells at 20 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
7. | ALA4623437 | Functional | Induction of apoptosis in human SK-MEL-147 cells assessed as late apoptotic cells at 20 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
8. | ALA4623438 | Functional | Induction of apoptosis in human SK-MEL-147 cells assessed as necrotic cells at 20 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
9. | ALA4623439 | Functional | Induction of apoptosis in human SK-MEL-147 cells assessed as mitochondrial membrane potential dissipation after 24 hrs by TMRM staining based fluorescence microscopic method | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
10. | ALA4623440 | Functional | Induction of apoptosis in human SK-MEL-147 cells assessed as increase in reactive oxygen species generation by CM-H2DCFDA staining based flow cytometric analysis | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
11. | ALA4623441 | Functional | Induction of apoptosis in human SK-MEL-147 cells assessed mitochondrial permeabilization after 24 hrs by mitotracker green staining based microscopic analysis | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
12. | ALA4623442 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of DTT measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
13. | ALA4623443 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of N-acetyl cysteine measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
14. | ALA4623444 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of EGTA measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
15. | ALA4623445 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of BAPTA measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
16. | ALA4623446 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of Boc-D-FMK measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
17. | ALA4623447 | Functional | Cytotoxicity against human SK-MEL-147 cells assessed as reduction in cell viability at EC50 concentration preincubated for 1 hr in presence of E-64 measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4622851 | cell-based format | Scientific Literature | |
18. | ALA4623448 | Functional | Induction of mitochondrial permeabilization in rat liver mitochondria assessed as mitochondrial transmembrane potential dissipation by rhodamine-123 dye based spectrofluorometer analysis | Rattus norvegicus | 2 | ALA4622851 | mitochondrion format | Scientific Literature | |
19. | ALA4623449 | Functional | Induction of mitochondrial permeabilization in rat liver mitochondria assessed as calcium efflux by calcium green based spectrofluorometer analysis | Rattus norvegicus | 2 | ALA4622851 | mitochondrion format | Scientific Literature | |
20. | ALA4623450 | Functional | Induction of mitochondrial permeabilization in rat liver mitochondria assessed as mitochondrial transmembrane potential dissipation in presence of DTT by rhodamine-123 dye based spectrofluorometer analysis | Rattus norvegicus | 2 | ALA4622851 | mitochondrion format | Scientific Literature |