| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4626518 | B | Inhibition of SCD in human NCI-H2122 cells expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
| 2. | ALA4626519 | A | Inhibition of SCD in human H2009 cells non-expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 3. | ALA4626520 | A | Inhibition of SCD in human H1819 cells non-expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4626523 | A | Cmax in plasma of nod-SCID mouse xenografted with human NCI-H2122 cells at 10 mg/kg, ip BID for 3 weeks by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 5. | ALA4626524 | A | AUC in plasma of nod-SCID mouse xenografted with human NCI-H2122 cells at 10 mg/kg, ip BID for 3 weeks by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA4626530 | A | Half life in human NCI-H2122 cells at 100 nM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4626531 | A | Half life in human NCI-H1155 cells at 100 nM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4626532 | A | Half life in human NCI-H2122 cells at 100 nM in presence of CYP4F inhibitor HET0016 by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4626533 | A | Drug metabolism in human NCI-H2122 cells assessed as (R)-4-(amino(phenyl)methyl)-N-(6-hydroxybenzo[d]thiazol-2-yl)-benzamide formation at 100 nM by LC-MS/MS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4626534 | A | Drug metabolism in human NCI-H1155 cells assessed as (R)-4-(amino(phenyl)methyl)-N-(6-hydroxybenzo[d]thiazol-2-yl)-benzamide formation at 100 nM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4626535 | A | Drug metabolism in human NCI-H2122 cells assessed as (R)-4-(amino(phenyl)methyl)-N-(6-hydroxybenzo[d]thiazol-2-yl)-benzamide formation at 100 nM by in presence of CYP4F inhibitor HET0016 LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4626536 | B | Inhibition of SCD in human NCI-H1155 cells non-expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4626537 | F | Antitumor activity against human NCI-H2122 cells xenografted in nod-SCID mouse fed normal chow diet at 20 mg/kg, ip QD for 3 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4626538 | F | Antitumor activity against human NCI-H2122 cells xenografted in nod-SCID mouse fed normal chow diet at 10 mg/kg, ip BID for 3 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4626539 | F | Antitumor activity against human NCI-H2122 cells xenografted in nod-SCID mouse fed fat-free diet at 20 mg/kg, ip QD for 3 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4626540 | F | Antitumor activity against human NCI-H2122 cells xenografted in nod-SCID mouse fed fat-free diet at 10 mg/kg, ip BID for 3 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4626541 | A | Drug level in plasma of normal chow diet fed nod-SCID mouse xenografted with NCI-H2122 cells at 20 mg/kg, ip QD for 3 weeks and measured 3 hrs after final dose by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4626542 | A | Drug level in tumor of normal chow diet fed nod-SCID mouse xenografted with NCI-H2122 cells at 20 mg/kg, ip QD for 3 weeks and measured 3 hrs after final dose by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4626543 | A | Drug level in plasma of fat-free diet fed nod-SCID mouse xenografted with NCI-H2122 cells at 20 mg/kg, ip QD for 3 weeks and measured 3 hrs after final dose by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4626544 | A | Drug level in tumor of fat-free diet fed nod-SCID mouse xenografted with NCI-H2122 cells at 20 mg/kg, ip QD for 3 weeks and measured 3 hrs after final dose by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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