| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4622222 | B | Displacement of 2-((1E,3E,5E)-5-(3,3-Dimethyl-1-(6-((4-(((3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)pyridin-2-yl)oxy)methyl)bicyclo[2.2.2]octan-1-yl)amino)-6-oxohexyl)-5-sulfoindolin-2-ylidene)penta-1,3-dien-1-yl)-1-ethyl-3,3-dimethyl-5-sulfo-3H-indol-1-ium trifluoroacetate from biotinylated human TLR8 extracellular domain (27 to 827 residues) expressed in Drosophila S2 cells after 30 mins by europium-labeled streptavidin based TR-FRET assay | Homo sapiens | 27 | ALA4619804 | cell-based format | Scientific Literature | |
| 2. | ALA4622223 | B | Antagonist activity at TLR4 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS addition and measured after 20 hrs by HTRF assay | Homo sapiens | 7 | ALA4619804 | cell-based format | Scientific Literature | |
| 3. | ALA4622224 | B | Antagonist activity at TLR7 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followed by ssRNA40 addition measured after 20 hrs by alphaLISA | Homo sapiens | 7 | ALA4619804 | cell-based format | Scientific Literature | |
| 4. | ALA4622225 | B | Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ssRNA40 addition measured after 20 hrs by HTRF assay | Homo sapiens | 26 | ALA4619804 | cell-based format | Scientific Literature | |
| 5. | ALA4622226 | B | Antagonist activity at TLR9 in human PBMC assessed as inhibition of ODN2216-induced IFNalpha production preincubated for 30 mins followed by ODN2216 addition and measured after 20 hrs by alphaLISA | Homo sapiens | 7 | ALA4619804 | cell-based format | Scientific Literature | |
| 6. | ALA4622228 | P | Dissociation constant, pKa of the compound | 22 | ALA4619804 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4622229 | P | Lipophilicity, log D of the compound | 6 | ALA4619804 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4622230 | P | Aqueous solubility of the compound at pH 6.8 | 2 | ALA4619804 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4622231 | A | Apparent permeability in MDCK cells | Canis lupus familiaris | 6 | ALA4619804 | cell-based format | Scientific Literature | |
| 10. | ALA4622232 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 2 | ALA4619804 | microsome format | Scientific Literature | |
| 11. | ALA4622233 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 2 | ALA4619804 | microsome format | Scientific Literature | |
| 12. | ALA4622234 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4619804 | single protein format | Scientific Literature | |
| 13. | ALA4622236 | B | Antagonist activity at TLR7 in human whole blood assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followed by ssRNA40 addition measured after 20 hrs by ELISA | Homo sapiens | 1 | ALA4619804 | tissue-based format | Scientific Literature | |
| 14. | ALA4622237 | B | Antagonist activity at TLR8 in human whole blood assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ssRNA40 addition measured after 20 hrs by HTRF assay | Homo sapiens | 1 | ALA4619804 | tissue-based format | Scientific Literature | |
| 15. | ALA4622238 | B | Antagonist activity at TLR9 in human whole blood inhibition of DOTAP-ODN2216-induced IFNalpha production preincubated for 30 mins followed by DOTAP-ODN2216 addition and measured after 20 hrs by ELISA | Homo sapiens | 1 | ALA4619804 | tissue-based format | Scientific Literature | |
| 16. | ALA4622239 | B | Antagonist activity at TLR7 in mouse whole blood assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followed by ssRNA40 addition measured after 20 hrs by ELISA | Mus musculus | 1 | ALA4619804 | tissue-based format | Scientific Literature | |
| 17. | ALA4622240 | B | Antagonist activity at TLR9 in mouse whole blood inhibition of DOTAP-ODN2216-induced IFNalpha production preincubated for 30 mins followed by DOTAP-ODN2216 addition and measured after 20 hrs by ELISA | Mus musculus | 1 | ALA4619804 | tissue-based format | Scientific Literature | |
| 18. | ALA4622241 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 1 | ALA4619804 | microsome format | Scientific Literature | |
| 19. | ALA4622242 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv or 3 mg/kg, po by LC/MS analysis | Rattus norvegicus | 1 | ALA4619804 | organism-based format | Scientific Literature | |
| 20. | ALA4622243 | A | Clearance in C57BL/6 mouse at 1 mg/kg, iv or 3 mg/kg, po by LC/MS analysis | Mus musculus | 1 | ALA4619804 | organism-based format | Scientific Literature |
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