| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4610689 | F | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 2. | ALA4610690 | F | Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization relative to acetylcholine | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 3. | ALA4610691 | B | Positive allosteric modulation of rat muscarinic M4 receptor | Rattus norvegicus | 16 | single protein format | Scientific Literature | ||
| 4. | ALA4610692 | A | Intrinsic clearance in rat microsomes | Rattus norvegicus | 8 | microsome format | Scientific Literature | ||
| 5. | ALA4610693 | A | Intrinsic clearance in human microsomes | Homo sapiens | 8 | microsome format | Scientific Literature | ||
| 6. | ALA4610694 | A | Unbound fraction in rat plasma | Rattus norvegicus | 8 | cell-free format | Scientific Literature | ||
| 7. | ALA4610695 | A | Unbound fraction in human plasma | Homo sapiens | 8 | cell-free format | Scientific Literature | ||
| 8. | ALA4610696 | A | Unbound fraction in rat brain | Rattus norvegicus | 8 | tissue-based format | Scientific Literature | ||
| 9. | ALA4610697 | A | Brain to plasma permeability coefficient, Kp of the compound in Sprague-Dawley rat at 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
| 10. | ALA4610698 | A | Unbound brain-to-plasma concentration ratio in Sprague-Dawley rat at 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 8 | organism-based format | Scientific Literature |
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