| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4619595 | F | Antiproliferative activity against human K562 cells incubated for 3 days by CCK8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4619597 | A | Antiproliferative activity against wild type mouse BA/F3 cells incubated for 3 days by CCK8 assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA4619598 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant driven cell viability incubated for 3 days by CCK8 assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 4. | ALA4619602 | B | Protac activity at Cereblon/BCR/ABL T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in BCR-ABL T315I mutant protein levels at 3 to 30000 nM incubated for 48 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4672965 | B | Protac binding affinity at CRBN/BCR-ABL (unknown origin) assessed as binding to phosphorylated c-ABL kinase domain by Kinomescan assay | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 6. | ALA4672966 | B | Protac binding affinity at CRBN/BCR-ABL (unknown origin) assessed as binding to non phosphorylated c-ABL kinase domain by Kinomescan assay | Homo sapiens | 5 | protein format | Scientific Literature | ||
| 7. | ALA4672967 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 2.5 uM incubated for 24 hrs by western blot analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4672968 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 1 uM incubated for 24 hrs by western blot analysis relative to control | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4672970 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as cell viability incubated for 48 hrs by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4774496 | B | Induction of CRBN-mediated BCR-ABL degradation in human K562 cells at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4832093 | F | Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 12. | ALA4832094 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as degrading activity by Western blotting analysis | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 13. | ALA5109011 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels incubated for 24 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5242508 | B | Protac activity at CRBN/BCR-ABL in human K562 cells at 1 uM by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5242509 | F | Cytotoxicity against human K562 cells assessed as cell growth inhibition | Homo sapiens | 1 | cell-based format | Scientific Literature |
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