# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4622176 | A | Fraction unbound in human plasma | Homo sapiens | 16 | ALA4619803 | cell-free format | Scientific Literature | |
2. | ALA4622177 | A | Fraction unbound in mouse plasma | Mus musculus | 16 | ALA4619803 | cell-free format | Scientific Literature | |
3. | ALA4622179 | B | Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abeta42 production after 24 hrs by Alphalisa assay | Homo sapiens | 21 | ALA4619803 | cell-based format | Scientific Literature | |
4. | ALA4622180 | B | Modulation of mouse gamma secretase assessed as reduction in Abeta42 production | Mus musculus | 13 | ALA4619803 | assay format | Scientific Literature | |
5. | ALA4622184 | P | Octanol/water distribution co-efficient, log D of the compound at pH 7.4 | 20 | ALA4619803 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4622185 | P | Solubility of compound by lyophilisation solubility assay | 20 | ALA4619803 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4622186 | A | Clearance in human hepatocytes assessed per million cells | Homo sapiens | 15 | ALA4619803 | cell-based format | Scientific Literature | |
8. | ALA4622187 | A | Clearance in mouse hepatocytes assessed per million cells | Mus musculus | 16 | ALA4619803 | cell-based format | Scientific Literature | |
9. | ALA4622188 | B | Inhibition of human Pgp assessed as efflux ratio | Homo sapiens | 6 | ALA4619803 | single protein format | Scientific Literature | |
10. | ALA4622189 | B | Inhibition of human ERG | Homo sapiens | 6 | ALA4619803 | single protein format | Scientific Literature | |
11. | ALA4622190 | B | Inhibition of mouse Pgp assessed as efflux ratio | Mus musculus | 6 | ALA4619803 | assay format | Scientific Literature | |
12. | ALA4622191 | A | Binding affinity to PIK4CB (unknown origin) | Homo sapiens | 10 | ALA4619803 | single protein format | Scientific Literature | |
13. | ALA4622192 | A | Glutathione reactivity of the compound assessed as GSH-adduct formation | 3 | ALA4619803 | assay format | Scientific Literature | ||
14. | ALA4622194 | A | Inhibition of human Notch1 expressed in HEK293 cells coexpressing luciferase reporter measured after 20 hrs by steady-glo chemiluminescence assay | Homo sapiens | 3 | ALA4619803 | cell-based format | Scientific Literature | |
15. | ALA4622195 | A | Fraction unbound in rat plasma | Rattus norvegicus | 3 | ALA4619803 | cell-free format | Scientific Literature | |
16. | ALA4622196 | A | Clearance in rat hepatocytes assessed per million cell | Rattus norvegicus | 3 | ALA4619803 | cell-based format | Scientific Literature | |
17. | ALA4622208 | T | Mutagenicity in Salmonella typhimurium by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 3 | ALA4619803 | assay format | Scientific Literature | |
18. | ALA4622209 | P | Solubility of the compound in fasted state simulated intestinal fluid | 3 | ALA4619803 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4622210 | P | Solubility in fed state simulated intestinal fluids | 3 | ALA4619803 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4622211 | A | Phototoxicity in human Keratinocytes in presence of UVA at 320 to 400 nm | Homo sapiens | 6 | ALA4619803 | cell-based format | Scientific Literature |