| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4614670 | A | Cytotoxicity against CHOK1 cells assessed as effect on cell growth up to 6 uM measured after 48 hrs by MTS assay | Cricetulus griseus | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 2. | ALA4614672 | B | Inhibition of polyamine transporter in DFMO-treated CHOK1 cells assessed as prevention of spermidine entry into cells by measuring rescue of DFMO-induced reduction in cell growth at 1 to 6 uM measured after 48 hrs in presence of amine oxidase suppressor aminoguanidine by MTS assay | Cricetulus griseus | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 3. | ALA4614673 | B | Inhibition of polyamine transporter in CHOK1 cells assessed as rescue of 2.4 uM N-(anthracenylmethyl) homospermidine-induced toxicity by measuring cell growth at 7 uM measured after 48 hrs in presence of amine oxidase suppressor aminoguanidine by MTS assay (Rvb = 23%) | Cricetulus griseus | 2 | ALA4613249 | cell-based format | Scientific Literature | |
| 4. | ALA4614674 | A | Cytotoxicity against CHOK1 cells assessed as effect on cell growth at < 7 uM measured after 48 hrs by MTS assay | Cricetulus griseus | 2 | ALA4613249 | cell-based format | Scientific Literature | |
| 5. | ALA4614675 | F | Potentiation of 0.5 uM N-(anthracenylmethyl) homospermidine-induced toxicity in CHOK1 cells assessed as increase in Ant-44-induced reduction in cell growth measured after 48 hrs in presence of amine oxidase suppressor aminoguanidine by MTS assay | Cricetulus griseus | 2 | ALA4613249 | cell-based format | Scientific Literature | |
| 6. | ALA4614676 | F | Potentiation of 0.5 uM N-(anthracenylmethyl) homospermidine-induced toxicity in CHOK1 cells assessed as increase in Ant-44-induced reduction in cell growth at 5 uM measured after 48 hrs in presence of amine oxidase suppressor aminoguanidine by microscopy analysis | Cricetulus griseus | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 7. | ALA4614677 | A | Cytotoxicity against human L3.6PL cells assessed as reduction in cell viability measured after 72 hrs by MTS assay | Homo sapiens | 2 | ALA4613249 | cell-based format | Scientific Literature | |
| 8. | ALA4614679 | A | Cytotoxicity against human L3.6PL cells assessed as reduction in cell viability at 1 uM measured after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 9. | ALA4614680 | F | Potentiation of 2 uM N-(anthracenylmethyl) homospermidine-induced toxicity in human L3.6PL cells assessed as increase in Ant-44-induced reduction in cell growth measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by MTS assay | Homo sapiens | 2 | ALA4613249 | cell-based format | Scientific Literature | |
| 10. | ALA4614681 | F | Effect on polyamine level in human L3.6PL cells assessed as decrease in intracellular spermidine level at 2 to 7 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 11. | ALA4614682 | F | Effect on polyamine level in human L3.6PL cells assessed as decrease in intracellular spermine level at 2 to 7 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 12. | ALA4614683 | F | Effect on polyamine level in human L3.6PL cells assessed as change in putrescine level at 2 to 7 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 13. | ALA4614684 | A | Cytotoxicity against human L3.6PL cells assessed as reduction in cell viability at 0.25 to 20 uM measured after 24 to 72 hrs by MTS assay | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 14. | ALA4614685 | F | Effect on polyamine level in human L3.6PL cells assessed as putrescine level per mg protein in supernatant at 2 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 977 +/- 522 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 15. | ALA4614686 | F | Effect on polyamine level in human L3.6PL cells assessed as putrescine level per mg protein in supernatant at 5 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 977 +/- 522 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 16. | ALA4614687 | F | Effect on polyamine level in human L3.6PL cells assessed as spermidine level per mg protein in supernatant at 2 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 339 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 17. | ALA4614688 | F | Effect on polyamine level in human L3.6PL cells assessed as spermidine level per mg protein in supernatant at 5 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 339 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 18. | ALA4614689 | F | Effect on polyamine level in human L3.6PL cells assessed as acetyl spermidine level per mg protein in supernatant at 2 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 1936 +/- 1365 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 19. | ALA4614690 | F | Effect on polyamine level in human L3.6PL cells assessed as acetyl spermidine level per mg protein in supernatant at 5 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 1936 +/- 1365 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature | |
| 20. | ALA4614691 | F | Effect on polyamine level in human L3.6PL cells assessed as spermine level per mg protein in supernatant at 2 uM measured after 72 hrs in presence of amine oxidase suppressor aminoguanidine by LCMS analysis (Rvb = 6152 +/- 5596 pmol/mg) | Homo sapiens | 1 | ALA4613249 | cell-based format | Scientific Literature |
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