# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4628855 | Binding | Displacement of [3H]-DAMGO from Wistar rat mu opioid receptor incubated for 1 hr by liquid scintillation counting method | Rattus norvegicus | 16 | ALA4627340 | single protein format | Scientific Literature | |
2. | ALA4628856 | Binding | Displacement of [3H]-DPDPE from Wistar rat delta opioid receptor incubated for 3 hrs by liquid scintillation counting method | Rattus norvegicus | 16 | ALA4627340 | single protein format | Scientific Literature | |
3. | ALA4628857 | Binding | Displacement of[3H]-U69,593 from Wistar rat kappa opioid receptor incubated for 1.5 hrs by liquid scintillation counting method | Rattus norvegicus | 16 | ALA4627340 | single protein format | Scientific Literature | |
4. | ALA4628858 | Functional | Agonist activity at mu opioid receptor (unknown origin) expressed in human HEK293 cells assessed as increase in cAMP accumulation using [3H]-cAMP as substrate measured after 30mins by liquid scintillation counting method | Homo sapiens | 16 | ALA4627340 | cell-based format | Scientific Literature | |
5. | ALA4628859 | Binding | Selectivity index, Ki for displacement of [3H]-DPDPE from Wistar rat delta opioid receptor to Ki for displacement of [3H]-DAMGO from Wistar rat mu opioid receptor | Rattus norvegicus | 5 | ALA4627340 | assay format | Scientific Literature | |
6. | ALA4628860 | ADME | Half life in Kunming mouse brain homogenate at 10'-2 mol/L by RP-HPLC analysis | Mus musculus | 6 | ALA4627340 | tissue-based format | Scientific Literature | |
7. | ALA4628861 | ADME | Half life in Kunming mouse serum at 10'-2 mol/L by RP-HPLC analysis | Mus musculus | 6 | ALA4627340 | cell-free format | Scientific Literature | |
8. | ALA4628862 | Functional | Antinociceptive activity in kunming mouse models assessed as inhibition of tail-flick response by tail-flick assay | Mus musculus | 6 | ALA4627340 | organism-based format | Scientific Literature | |
9. | ALA4628863 | Functional | Antinociceptive activity in kunming mouse models assessed as maximum possible effect at 0.4 nmol, icv measured from 5 to 60 mins by warm water tail-flick assay relative to control | Mus musculus | 6 | ALA4627340 | organism-based format | Scientific Literature | |
10. | ALA4628864 | Functional | Antinociceptive activity in kunming mouse models of formalin-induced hyperalgesia assessed as reduction in pain response of paw licking inflammatory phase at 0.04 nmol, icv measured during phase 1 at 0 to 5 mins relative to control | Mus musculus | 3 | ALA4627340 | organism-based format | Scientific Literature | |
11. | ALA4628865 | Functional | Antinociceptive activity in icv administered kunming mouse models of formalin-induced hyperalgesia assessed reduction in pain response of paw licking during inflammatory phase 2 at 15 to 30 mins | Mus musculus | 3 | ALA4627340 | organism-based format | Scientific Literature | |
12. | ALA4628866 | Functional | Antinociceptive activity in kunming mouse models assessed as effective dose after icv administration measured from 5 to 60 mins by warm water tail-flick assay | Mus musculus | 6 | ALA4627340 | organism-based format | Scientific Literature | |
13. | ALA4628871 | Functional | Antinociceptive activity in icv administered kunming mouse models of formalin-induced hyperalgesia assessed reduction in time spent on paw biting during inflammatory phase 2 at 15 to 30 mins | Mus musculus | 3 | ALA4627340 | organism-based format | Scientific Literature | |
14. | ALA4628872 | Functional | Agonist activity at mu opioid receptor (unknown origin) expressed in human HEK293 cells assessed as increase in cAMP accumulation using [3H]-cAMP as substrate measured after 30mins by liquid scintillation counting method relative to control | Homo sapiens | 16 | ALA4627340 | cell-based format | Scientific Literature | |
15. | ALA4628874 | Functional | Antinociceptive activity in kunming mouse models assessed as maximum possible effect at 4 nmol, icv measured from 5 to 60 mins by warm water tail-flick assay relative to control | Mus musculus | 6 | ALA4627340 | organism-based format | Scientific Literature | |
16. | ALA4628875 | Functional | Potency index, ratio of EM1 ED50 to test compound ED50 for antinociceptive activity in icv administered kunming mouse | Mus musculus | 4 | ALA4627340 | organism-based format | Scientific Literature | |
17. | ALA4628876 | Functional | Potency index, ratio of EM2 ED50 to test compound ED50 for antinociceptive activity in icv administered kunming mouse | Mus musculus | 4 | ALA4627340 | organism-based format | Scientific Literature | |
18. | ALA4628877 | Functional | Antinociceptive activity in kunming mouse models of formalin-induced hyperalgesia assessed as reduction in time spent on paw biting inflammatory phase at 0.04 nmol, icv measured during phase 1 at 0 to 5 mins relative to control | Mus musculus | 3 | ALA4627340 | organism-based format | Scientific Literature | |
19. | ALA4628878 | Functional | Antinociceptive activity in kunming mouse models of formalin-induced hyperalgesia assessed as reduction in time spent on paw shaking inflammatory phase at 0.04 nmol, icv measured during phase 1 at 0 to 5 mins relative to control | Mus musculus | 3 | ALA4627340 | organism-based format | Scientific Literature | |
20. | ALA4628879 | Functional | Antinociceptive activity in icv administered kunming mouse models of formalin-induced hyperalgesia assessed reduction in time spent on paw shaking during inflammatory phase 2 at 15 to 30 mins | Mus musculus | 3 | ALA4627340 | organism-based format | Scientific Literature |