| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4628855 | B | Displacement of [3H]-DAMGO from Wistar rat mu opioid receptor incubated for 1 hr by liquid scintillation counting method | Rattus norvegicus | 16 | single protein format | Scientific Literature | ||
| 2. | ALA4628856 | B | Displacement of [3H]-DPDPE from Wistar rat delta opioid receptor incubated for 3 hrs by liquid scintillation counting method | Rattus norvegicus | 16 | single protein format | Scientific Literature | ||
| 3. | ALA4628857 | B | Displacement of[3H]-U69,593 from Wistar rat kappa opioid receptor incubated for 1.5 hrs by liquid scintillation counting method | Rattus norvegicus | 16 | single protein format | Scientific Literature | ||
| 4. | ALA4628858 | F | Agonist activity at mu opioid receptor (unknown origin) expressed in human HEK293 cells assessed as increase in cAMP accumulation using [3H]-cAMP as substrate measured after 30mins by liquid scintillation counting method | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 5. | ALA4628859 | B | Selectivity index, Ki for displacement of [3H]-DPDPE from Wistar rat delta opioid receptor to Ki for displacement of [3H]-DAMGO from Wistar rat mu opioid receptor | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
| 6. | ALA4628860 | A | Half life in Kunming mouse brain homogenate at 10'-2 mol/L by RP-HPLC analysis | Mus musculus | 6 | tissue-based format | Scientific Literature | ||
| 7. | ALA4628861 | A | Half life in Kunming mouse serum at 10'-2 mol/L by RP-HPLC analysis | Mus musculus | 6 | cell-free format | Scientific Literature | ||
| 8. | ALA4628862 | F | Antinociceptive activity in kunming mouse models assessed as inhibition of tail-flick response by tail-flick assay | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA4628863 | F | Antinociceptive activity in kunming mouse models assessed as maximum possible effect at 0.4 nmol, icv measured from 5 to 60 mins by warm water tail-flick assay relative to control | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA4628864 | F | Antinociceptive activity in kunming mouse models of formalin-induced hyperalgesia assessed as reduction in pain response of paw licking inflammatory phase at 0.04 nmol, icv measured during phase 1 at 0 to 5 mins relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA4628865 | F | Antinociceptive activity in icv administered kunming mouse models of formalin-induced hyperalgesia assessed reduction in pain response of paw licking during inflammatory phase 2 at 15 to 30 mins | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA4628866 | F | Antinociceptive activity in kunming mouse models assessed as effective dose after icv administration measured from 5 to 60 mins by warm water tail-flick assay | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 13. | ALA4628871 | F | Antinociceptive activity in icv administered kunming mouse models of formalin-induced hyperalgesia assessed reduction in time spent on paw biting during inflammatory phase 2 at 15 to 30 mins | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4628872 | F | Agonist activity at mu opioid receptor (unknown origin) expressed in human HEK293 cells assessed as increase in cAMP accumulation using [3H]-cAMP as substrate measured after 30mins by liquid scintillation counting method relative to control | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 15. | ALA4628874 | F | Antinociceptive activity in kunming mouse models assessed as maximum possible effect at 4 nmol, icv measured from 5 to 60 mins by warm water tail-flick assay relative to control | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 16. | ALA4628875 | F | Potency index, ratio of EM1 ED50 to test compound ED50 for antinociceptive activity in icv administered kunming mouse | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA4628876 | F | Potency index, ratio of EM2 ED50 to test compound ED50 for antinociceptive activity in icv administered kunming mouse | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 18. | ALA4628877 | F | Antinociceptive activity in kunming mouse models of formalin-induced hyperalgesia assessed as reduction in time spent on paw biting inflammatory phase at 0.04 nmol, icv measured during phase 1 at 0 to 5 mins relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4628878 | F | Antinociceptive activity in kunming mouse models of formalin-induced hyperalgesia assessed as reduction in time spent on paw shaking inflammatory phase at 0.04 nmol, icv measured during phase 1 at 0 to 5 mins relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4628879 | F | Antinociceptive activity in icv administered kunming mouse models of formalin-induced hyperalgesia assessed reduction in time spent on paw shaking during inflammatory phase 2 at 15 to 30 mins | Mus musculus | 3 | organism-based format | Scientific Literature |
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