Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from HA-tagged mouse P2Y14 expressed in HEK293 cells measured after 30 mins by FACScalibur flow cytometry analysis
Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from human P2Y14 expressed in CHO cells measured after 30 mins by FACScalibur flow cytometry analysis
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as reversal of mechanical allodynia at 10 umol/kg, ip administered 7 days post-surgery and measured after 30 mins to 3 hrs post-dose by Von Frey assay
Antinociceptive activity in ip dosed ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia administered 7 days post-surgery and measured after 1 hr post-dose by Von Frey assay
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 10 umol/kg, ip administered 7 days post-surgery and measured after 5 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 3 umol/kg, ip administered 7 days post-surgery and measured after 5 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 1 umol/kg, ip administered 7 days post-surgery and measured after 5 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 10 umol/kg, ip administered 7 days post-surgery and measured after 3 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 3 umol/kg, ip administered 7 days post-surgery and measured after 3 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 1 umol/kg, ip administered 7 days post-surgery and measured after 3 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 10 umol/kg, ip administered 7 days post-surgery and measured after 2 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 3 umol/kg, ip administered 7 days post-surgery and measured after 2 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 1 umol/kg, ip administered 7 days post-surgery and measured after 2 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 10 umol/kg, ip administered 7 days post-surgery and measured after 1 hr post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 3 umol/kg, ip administered 7 days post-surgery and measured after 1 hr post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 1 umol/kg, ip administered 7 days post-surgery and measured after 1 hr post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 10 umol/kg, ip administered 7 days post-surgery and measured after 0.5 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 3 umol/kg, ip administered 7 days post-surgery and measured after 0.5 hrs post-dose by Von Frey assay relative to control
Antinociceptive activity in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia at 1 umol/kg, ip administered 7 days post-surgery and measured after 0.5 hrs post-dose by Von Frey assay relative to control
Effect on nociception on contralateral paw in ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as paw withdrawal threshold at 10 umol/kg, ip administered 7 days post-surgery and measured after 30 mins to 3 hrs post-dose by Von Frey assay