| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4610787 | B | Inhibition of recombinant human His-tagged full length BTK expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 2. | ALA4610788 | B | Inhibition of recombinant human N-terminal GST-tagged JAK1 (850 to 1154 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 3. | ALA4610789 | B | Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 4. | ALA4610790 | B | Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 5. | ALA4610791 | B | Inhibition of recombinant human N-terminal GST-tagged TYK2 (871 to 1187 residues) expressed in baculovirus expression system using Ulight-Poly GT as substrate incubated for 2 hrs by Lanthascreen TR-FRET assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 6. | ALA4610792 | B | Selectivity index, ratio of IC50 for recombinant human N-terminal GST-tagged JAK1 (850 to 1154 residues) expressed in baculovirus expression system to IC50 for recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 7. | ALA4610793 | B | Selectivity index, ratio of IC50 for recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system to IC50 for recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 8. | ALA4610794 | B | Selectivity index, ratio of IC50 for recombinant human N-terminal GST-tagged TYK2 (871 to 1187 residues) expressed in baculovirus expression system to IC50 for recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 9. | ALA4610795 | F | Antiproliferative activity against human Raji cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4610796 | F | Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4610797 | F | Antiproliferative activity against human HEL cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4610798 | F | Antiproliferative activity against human JeKo1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4610799 | F | Antiproliferative activity against human OCI-LY10 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4610800 | A | Metabolic stability in human liver microsomes assessed as half life at 0.2 uM incubated for 60 mins by UPLC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 15. | ALA4610801 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.2 uM incubated for 60 mins by UPLC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 16. | ALA4610802 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 0.2 uM incubated for 60 mins by UPLC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature |
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