| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4606150 | Binding | Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 62 | ALA4602725 | single protein format | Scientific Literature | |
| 2. | ALA4606151 | Binding | Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 7 | ALA4602725 | single protein format | Scientific Literature | |
| 3. | ALA4606152 | Binding | Inhibition of human recombinant HDAC3 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 7 | ALA4602725 | single protein format | Scientific Literature | |
| 4. | ALA4606153 | Binding | Inhibition of human recombinant HDAC8 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 7 | ALA4602725 | single protein format | Scientific Literature | |
| 5. | ALA4606154 | Binding | Inhibition of human recombinant HDAC7 pre-incubated for 15 mins before Ac-Leu-Gly-Lys(trifluroAc)-AMC substrate addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 7 | ALA4602725 | single protein format | Scientific Literature | |
| 6. | ALA4606156 | Binding | Selectivity index, ratio of IC50 for inhibition of human recombinant HDAC2 to IC50 for inhibition of human recombinant HDAC1 | Homo sapiens | 7 | ALA4602725 | assay format | Scientific Literature | |
| 7. | ALA4606157 | Binding | Selectivity index, ratio of IC50 for inhibition of human recombinant HDAC8 to IC50 for inhibition of human recombinant HDAC1 | Homo sapiens | 7 | ALA4602725 | assay format | Scientific Literature | |
| 8. | ALA4606158 | Binding | Selectivity index, ratio of IC50 for inhibition of human recombinant HDAC3 to IC50 for inhibition of human recombinant HDAC1 | Homo sapiens | 7 | ALA4602725 | assay format | Scientific Literature | |
| 9. | ALA4606159 | Binding | Potency index, ratio of IC50 for AR-42 to IC50 for test compound for inhibition of human recombinant HDAC1 pre-incubated for 30 mins before Ac-Leu- Gly-Lys(Ac)-AMC substrate addition and measured after 90 mins by fluorescence based assay | Homo sapiens | 1 | ALA4602725 | single protein format | Scientific Literature | |
| 10. | ALA4606160 | Binding | Selectivity index, ratio of IC50 for inhibition of human recombinant HDAC7 to IC50 for inhibition of human recombinant HDAC1 | Homo sapiens | 7 | ALA4602725 | assay format | Scientific Literature | |
| 11. | ALA4606161 | Functional | Potency index, ratio of IC50 for AR-42 to IC50 for test compound for cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 3 | ALA4602725 | cell-based format | Scientific Literature | |
| 12. | ALA4606162 | Functional | Potency index, ratio of IC50 for AR-42 to IC50 for test compound for cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 3 | ALA4602725 | cell-based format | Scientific Literature | |
| 13. | ALA4606163 | Functional | Potency index, ratio of IC50 for AR-42 to IC50 for test compound for cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 3 | ALA4602725 | cell-based format | Scientific Literature | |
| 14. | ALA4606164 | Functional | Potency index, ratio of IC50 for AR-42 to IC50 for test compound for cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 3 | ALA4602725 | cell-based format | Scientific Literature | |
| 15. | ALA4606165 | Functional | Potency index, ratio of IC50 for AR-42 to IC50 for test compound for cytotoxicity against human MM96L cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 3 | ALA4602725 | cell-based format | Scientific Literature | |
| 16. | ALA4606166 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human neonatal foreskin fibroblasts by MTT assay to IC50 for cytotoxicity against human A549 cells by MTT assay | Homo sapiens | 2 | ALA4602725 | cell-based format | Scientific Literature | |
| 17. | ALA4606167 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human neonatal foreskin fibroblasts by MTT assay to IC50 for cytotoxicity against human HT-29 cells by MTT assay | Homo sapiens | 2 | ALA4602725 | cell-based format | Scientific Literature | |
| 18. | ALA4606168 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human neonatal foreskin fibroblasts by MTT assay to IC50 for cytotoxicity against human HeLa cells by MTT assay | Homo sapiens | 2 | ALA4602725 | cell-based format | Scientific Literature | |
| 19. | ALA4606169 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human neonatal foreskin fibroblasts by MTT assay to IC50 for cytotoxicity against human MDA-MB-231 cells by MTT assay | Homo sapiens | 2 | ALA4602725 | cell-based format | Scientific Literature | |
| 20. | ALA4606170 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human neonatal foreskin fibroblasts by MTT assay to IC50 for cytotoxicity against human MM96L cells by MTT assay | Homo sapiens | 2 | ALA4602725 | cell-based format | Scientific Literature |
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