| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4604220 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation at 1 uM after 12 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4604224 | B | Protac activity at CRBN/CDK2 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation at 50 nM after 12 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4604225 | B | Protac activity at CRBN/CDK9 in AR-negative human PC3 cells assessed as induction of CDK9 protein degradation at 50 nM after 12 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4604226 | F | Antiproliferative activity against AR-negative human PC3 cells assessed as reduction in cell viability after 5 days by CCK8 assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 5. | ALA4604227 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as induction of CDK2 protein degradation after 24 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4604228 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as induction of CDK9 protein degradation after 24 hrs by Western blot analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA4604229 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as induction of CDK9 protein degradation at 500 nM after 4 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4604230 | B | Protac activity at CRBN/CDK4 in AR-negative human PC3 cells assessed as induction of CDK4 protein degradation at 500 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4604231 | B | Protac activity at CRBN/CDK6 in AR-negative human PC3 cells assessed as induction of CDK4 protein degradation at 500 nM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4604232 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as reduction in c-Myc protein expression at 500 nM measured after 2 to 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4604233 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as CDK2 degradation at 250 nM preincubated with pomalidomide for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4604234 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as CDK2 degradation at 250 nM preincubated with FN-1501 for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4604235 | B | Protac activity at CRBN/CDK2/CDK9 in AR-negative human PC3 cells assessed as CDK2 degradation at 250 nM preincubated with proteasome inhibitor MG132 for 2 hrs and measured after 8 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4604241 | A | Cytotoxicity against human LO2 cells assessed as reduction in cell viability after 5 days by CCK-8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4604242 | B | Inhibition of tracer K10 binding to NanoLuc-CDK2/Cyclin A (unknown origin) expressed in human HEK293 cells after 1 hr in presence of ATP by NanoBRET assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4604243 | B | Inhibition of tracer K10 binding to NanoLuc-CDK9/Cyclin T1 (unknown origin) expressed in human HEK293 cells after 1 hr in presence of ATP by NanoBRET assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4604244 | B | Protac activity at CRBN/CDK2/CDK9 in human MCF7 cells assessed as CDK2 degradation at 0.25 to 10 uM after 12 hrs by Westernblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4604245 | B | Protac activity at CRBN/CDK2/CDK9 in human HCT116 cells assessed as CDK2 degradation at 0.25 to 10 uM after 12 hrs by Westernblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4604246 | B | Protac activity at CRBN/CDK2/CDK9 in human 22Rv1 cells assessed as CDK2 degradation at 0.25 to 10 uM after 12 hrs by Westernblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4604247 | F | Induction of cell cycle arrest in human PC3 cells assessed as accumulation at G0/G1 phase at 250 nM after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 59.80%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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