# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4612762 | B | Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA1 expressed in baculovirus infected Sf9 insect cells using FRET-labeled Ser/Thr 12 as substrate measured after 1 hr by Z'-lyte assay | Homo sapiens | 23 | ALA4610118 | cell-based format | Scientific Literature | |
2. | ALA4612763 | B | Inhibition of recombinant human full-length His-tagged CDK7/Cyclin H/MNAT1 expressed in baculovirus infection system using Cdk7/9tide as substrate measured after 1 hr by Alexa Fluor 647 ADP Tracer-based Adapta assay | Homo sapiens | 23 | ALA4610118 | assay format | Scientific Literature | |
3. | ALA4612764 | B | Inhibition of recombinant human full-length His-tagged CDK9/Cyclin T1 expressed in baculovirus infection system using Cdk7/9tide as substrate measured after 1 hr in presence of Alexa Fluor 647 ADP Tracer-based Adapta assay | Homo sapiens | 23 | ALA4610118 | assay format | Scientific Literature | |
4. | ALA4612765 | B | Inhibition of biotinylated-THZ1 binding to CDK12/CDK13 in human Jurkat cells assessed as reduction in cyclin K pull down by measuring residual protein level at 500 nM preincubated for 6 hrs followed by biotinylated-THZ1 addition and measured Western blotting based pulldown assay relative to control | Homo sapiens | 23 | ALA4610118 | cell-based format | Scientific Literature | |
5. | ALA4739783 | B | Inhibition of CDK2 (unknown origin) | Homo sapiens | 37 | ALA4739712 | single protein format | Patent Bioactivity Data | |
6. | ALA4739784 | B | Inhibition of CDK7 (unknown origin) | Homo sapiens | 37 | ALA4739712 | single protein format | Patent Bioactivity Data | |
7. | ALA4739785 | B | Inhibition of CDK9 (unknown origin) | Homo sapiens | 37 | ALA4739712 | single protein format | Patent Bioactivity Data | |
8. | ALA4739791 | B | Inhibition of biotinylated-THZ1 binding to CDK12/CDK13 in human Jurkat cells assessed as reduction in cyclin K pull down at 500 nM preincubated for 6 hrs followed by biotinylated-THZ1 addition by Western blotting based pulldown assay | Homo sapiens | 13 | ALA4739712 | cell-based format | Patent Bioactivity Data | |
9. | ALA4739793 | F | Antiproliferative activity against human Jurkat cells measured after 72 hrs by Celltiter glo assay | Homo sapiens | 13 | ALA4739712 | cell-based format | Patent Bioactivity Data |