| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4622626 | B | Inhibition of CBR1 (unknown origin) | Homo sapiens | 7 | ALA4619820 | single protein format | Scientific Literature | |
| 2. | ALA4622627 | B | Inhibition of recombinant AKR1C3 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH level | Homo sapiens | 28 | ALA4619820 | single protein format | Scientific Literature | |
| 3. | ALA4622628 | B | Inhibition of recombinant AKR1C1 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH level | Homo sapiens | 7 | ALA4619820 | single protein format | Scientific Literature | |
| 4. | ALA4622629 | B | Inhibition of recombinant AKR1C2 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH level | Homo sapiens | 7 | ALA4619820 | single protein format | Scientific Literature | |
| 5. | ALA4622630 | B | Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH level | Homo sapiens | 7 | ALA4619820 | single protein format | Scientific Literature | |
| 6. | ALA4622631 | B | Ratio of IC50 for inhibition of recombinant AKR1C1 (unknown origin) inhibition of recombinant AKR1C3 (unknown origin) | Homo sapiens | 7 | ALA4619820 | assay format | Scientific Literature | |
| 7. | ALA4622632 | B | Ratio of IC50 for inhibition of recombinant AKR1C2 (unknown origin) inhibition of recombinant AKR1C3 (unknown origin) | Homo sapiens | 7 | ALA4619820 | assay format | Scientific Literature | |
| 8. | ALA4622633 | B | Ratio of IC50 for inhibition of recombinant AKR1C4 (unknown origin) inhibition of recombinant AKR1C3 (unknown origin) | Homo sapiens | 7 | ALA4619820 | assay format | Scientific Literature | |
| 9. | ALA4622634 | B | Ratio of IC50 for inhibition of CBR1 (unknown origin) inhibition of recombinant AKR1C3 (unknown origin) | Homo sapiens | 7 | ALA4619820 | assay format | Scientific Literature | |
| 10. | ALA4622635 | F | Inhibition of pregnenolone-induced cell proliferation of human 22Rv1 cells at 10 to 20 uM pre-incubated for 2 hrs before pregnenolone stimulation for 72 hrs by alamar blue assay | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 11. | ALA4622637 | F | Inhibition of pregnenolone-induced cell cell cycle changes in human 22Rv1 cells assessed as reduction in S phase accumulation at 10 uM pre-incubated for 2 hrs before pregnenolone stimulation for 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 12. | ALA4622638 | F | Inhibition of pregnenolone-induced cell cell cycle changes in human 22Rv1 cells assessed as increase in G0/GG1 phase accumulation at 10 uM pre-incubated for 2 hrs before pregnenolone stimulation for 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 13. | ALA4622639 | B | Inhibition of AKR1C3 in human 22Rv1 cells assessed as as reduction in finasteride-induced metabolism of 4AD into testosterone at 10 to 20 uM pre-incubated for 2 hrs in presence of finasteride before 4AD addition for 24 hrs by EIA | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 14. | ALA4622640 | B | Effect on steroid 5alpha-reductase in human 22Rv1 cells assessed as effect on metabolism of 4AD into testosterone at 10 to 20 uM pre-incubated for 2 hrs before 4AD addition for 24 hrs by EIA | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 15. | ALA4622641 | F | Effect on AKR1C3 gene expression in human 22Rv1 cells at 10 uM incubated for 24 hrs by semiquantitative RT-PCR analysis | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 16. | ALA4622642 | B | Inhibition of AKR1C3 in human 22Rv1 cells assessed as as reduction in AR nuclear translocation at 10 pre-incubated for 2 hrs before 4AD addition for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 17. | ALA4622643 | B | Inhibition of AKR1C3 in human 22Rv1 cells assessed as as reduction in AR nuclear translocation at 10 to 20 uM pre-incubated for 2 hrs in absence of finasteride by Western blot analysis | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 18. | ALA4622644 | B | Inhibition of AKR1C3 in human 22Rv1 cells assessed as as reduction in AR mRNA expression at 10 to 20 uM pre-incubated for 2 hrs before pregnenolone stimulation for 24 hrs by RT-qPCR analysis | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 19. | ALA4622645 | B | Inhibition of AKR1C3 in human 22Rv1 cells assessed as as reduction in TMPRSS2 mRNA expression at 10 to 20 uM pre-incubated for 2 hrs before pregnenolone stimulation for 24 hrs by RT-qPCR analysis | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature | |
| 20. | ALA4622646 | B | Inhibition of AKR1C3 in human 22Rv1 cells assessed as as reduction in PSA mRNA expression at 10 to 20 uM pre-incubated for 2 hrs before pregnenolone stimulation for 24 hrs by RT-qPCR analysis | Homo sapiens | 2 | ALA4619820 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!