# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4621277 | B | Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay | Ebolavirus | 26 | cell-based format | Scientific Literature | ||
2. | ALA4621278 | B | Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry at 12.5 uM measured after 48 hrs by luciferase reporter gene assay relative to control | Ebolavirus | 47 | cell-based format | Scientific Literature | ||
3. | ALA4621279 | B | Inhibition of pseudotyped HIV/MARV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay | Marburgvirus | 25 | cell-based format | Scientific Literature | ||
4. | ALA4621280 | B | Inhibition of pseudotyped HIV/MARV GP infected in human A549 cells assessed as reduction in virus entry at 12.5 uM measured after 48 hrs by luciferase reporter gene assay relative to control | Marburgvirus | 47 | cell-based format | Scientific Literature | ||
5. | ALA4621281 | T | Selectivity index, ratio of CC50 for human A549 cells to EC50 for HIV/EBOV-GP infected in human A549 cells | 26 | cell-based format | Scientific Literature | |||
6. | ALA4621282 | T | Selectivity index, ratio of CC50 for human A549 cells to EC50 for HIV/MARV-GP infected in human A549 cells | 26 | cell-based format | Scientific Literature | |||
7. | ALA4621283 | F | Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay | Zaire ebolavirus | 12 | organism-based format | Scientific Literature | ||
8. | ALA4621285 | F | Antiviral activity against Marburg virus Lake Victoria, 2005 Angola infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay | Lake Victoria marburgvirus | 12 | organism-based format | Scientific Literature | ||
9. | ALA4621286 | T | Selectivity index, ratio of CC50 for human HeLa cells to EC50 for Ebola virus 1976 Mayinga in human HeLa cells | 11 | cell-based format | Scientific Literature | |||
10. | ALA4621287 | B | Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entry | Ebolavirus | 3 | cell-based format | Scientific Literature | ||
11. | ALA4621288 | B | Inhibition of HIV/EBOV GP T519V mutant infected in 293T cells assessed as reduction in virus entry | Ebolavirus | 2 | cell-based format | Scientific Literature | ||
12. | ALA4621289 | A | Metabolic stability in human pooled plasma assessed as parent compound remaining at 20 uM after 60 mins by HPLC analysis | Homo sapiens | 11 | cell-free format | Scientific Literature | ||
13. | ALA4621290 | A | Metabolic stability in Sprague-Dawley rat pooled plasma assessed as parent compound remaining at 20 uM after 60 mins by HPLC analysis | Rattus norvegicus | 11 | cell-free format | Scientific Literature | ||
14. | ALA4621291 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 11 | microsome format | Scientific Literature | ||
15. | ALA4621292 | A | Metabolic stability in Fischer F344 rat liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by HPLC analysis | Rattus norvegicus | 11 | microsome format | Scientific Literature | ||
16. | ALA4621293 | A | Inhibition of recombinant human CYP3A4 expressed in baculovirus infected insect cell microsomes using vivid DBOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 25 mins in presence of NAD+ by fluorescence assay | Homo sapiens | 9 | microsome format | Scientific Literature | ||
17. | ALA4621294 | A | Inhibition of recombinant human CYP2C9 expressed in baculovirus infected insect cell microsomes using vivid BOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 25 mins in presence of NAD+ by fluorescence assay | Homo sapiens | 9 | microsome format | Scientific Literature |