| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4606092 | B | Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as potentiation of DOX-induced cytotoxicity by measuring inhibition of cell proliferation at 1 uM incubated for 48 hrs by SRB assay (Rvb = 5.3 +/- 3 %) | Homo sapiens | 47 | cell-based format | Scientific Literature | ||
| 2. | ALA4606093 | B | Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as potentiation of DOX-induced cytotoxicity by measuring DOX IC50 at 1 uM incubated for 48 hrs by SRB assay (Rvb = 33.39 +/- 7.08 uM) | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 3. | ALA4606094 | B | Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as potentiation of DOX-induced cytotoxicity by measuring change in DOX IC50 at 1 uM incubated for 48 hrs by SRB assay relative to DOX alone | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 4. | ALA4606095 | A | Cytotoxicity against human SW620/AD300 cells assessed as cell growth inhibition at 10 uM incubated for 48 hrs by SRB assay relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA4606096 | B | Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as concentration required to show half of DOX IC50 incubated for 48 hrs by SRB assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4606097 | F | Downregulation of ABCB1 expression in human SW620/AD300 cells at 1 to 5 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4606098 | B | Reversal of ABCB1-mediated multidrug resistance in human SW620 cells assessed as reduction in Rh123 efflux at 0.01 to 0.5 uM incubated for 4 hrs by flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4606099 | B | Reversal of ABCB1-mediated multidrug resistance in human SW620/AD300 cells assessed as reduction in Rh123 efflux incubated for 4 hrs by flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4606101 | B | Reversal of ABCG2-mediated mitoxantrone resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring change in mitoxantrone IC50 at 5 uM incubated for 48 hrs by SRB assay relative to mitoxantrone IC50 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4606102 | B | Reversal of ABCG2-mediated mitoxantrone resistance in human NCI-H460/MX20 cells assessed as potentiation of mitoxantrone-induced cytotoxicity by measuring change in mitoxantrone IC50 at 2.5 uM incubated for 48 hrs by SRB assay relative to mitoxantrone IC50 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4606104 | B | Reversal of ABCC1-mediated vincristine resistance in human KB-CV60 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring change in vincristine IC50 at 5 uM incubated for 48 hrs by SRB assay relative to vincristine IC50 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4606105 | B | Reversal of ABCC1-mediated vincristine resistance in human KB-CV60 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring change in vincristine IC50 at 2.5 uM incubated for 48 hrs by SRB assay relative to vincristine IC50 | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4606107 | B | Effect on recombinant human membrane bound ABCB1 ATPase activity 0.05 to 5 uM incubated for 5 mins followed by Mg-ATP addition and measured after 40 mins by luciferase reporter gene based p-gp glo assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4606108 | B | Binding affinity to ABCB1 in human SW620/AD300 cells assessed as increase in thermal stability of ABCB1 at 20 uM incubated for 30 to 60 mins followed by heating at 40.5 to 59.5 degC by CESTA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4606110 | F | Potentiation of DOX-induced anti tumor activity against human K562/A02 cells xenografted in BALB/c mouse assessed as tumor size at 30 mg/kg, iv administered every 2 days for 14 days measured during compound dosing by caliper method (Rvb = 610 mm3) | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4606111 | A | Effect on tumor size of human K562/A02 cells xenografted in BALB/c mouse at 30 mg/kg, iv administered every 2 days for 14 days measured during compound dosing by caliper method | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4606112 | F | Potentiation of DOX-induced anti tumor activity against human K562/A02 cells xenografted in BALB/c mouse assessed as reduction in tumor weight at 30 mg/kg, iv administered every 2 days for 14 days measured 24 hrs post-last dose | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4606113 | B | Reversal of ABCB1-mediated multidrug resistance in human SW620/AD300 cells assessed as increase in Rh123 accumulation at 0.01 to 0.5 uM incubated for 4 hrs by flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4606114 | F | Induction of Rh123 accumulation in human SW620 cells at 0.01 to 0.5 uM incubated for 4 hrs by flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4606115 | A | Cytotoxicity against human KB-CV60 cells assessed as effect on cell proliferation at 2.5 to 5 uM measured after 48 hrs by SRB assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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