# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4622293 | B | Inhibition of MRS4174 binding to human P2Y14R expressed in CHO cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins at pH 7.4 by flow cytomtery based competitive fluorescence assay | Homo sapiens | 29 | ALA4619807 | cell-based format | Scientific Literature | |
2. | ALA4622294 | B | Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins by flow cytomtery based competitive fluorescence assay | Mus musculus | 13 | ALA4619807 | cell-based format | Scientific Literature | |
3. | ALA4622297 | P | Solubility in 10% DMSO in water | 1 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4622300 | B | Binding affinity to sigma 2 receptor (unknown origin) | Homo sapiens | 7 | ALA4619807 | assay format | Scientific Literature | |
5. | ALA4622312 | P | Aqueous solubility at pH 7.4 by pION method | 6 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4622313 | P | Aqueous solubility at pH 4 by pION method | 6 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4622314 | P | Lipophilicity, change in Constant K of the compound by RP-HPLC analysis relative to PPTN | 6 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4622315 | A | Bioavailability in rat at 1 to 10 mg/kg, ip | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
9. | ALA4622316 | A | Cmax in rat at 10 mg/kg, ip after 3 to 4 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
10. | ALA4622317 | A | Tmax in rat at 10 mg/kg, ip | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
11. | ALA4622318 | A | Drug level in rat at 10 mg/kg, ip after 12 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
12. | ALA4622319 | A | Plasma concentration in rat at 1 mg/kg, ip after 2 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
13. | ALA4622320 | A | Plasma concentration in rat at 1 mg/kg, ip after 4 hrs | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
14. | ALA4622321 | A | Half life in rat at 1 mg/kg, ip | Rattus norvegicus | 2 | ALA4619807 | organism-based format | Scientific Literature | |
15. | ALA4622322 | A | Permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 2 | ALA4619807 | cell-based format | Scientific Literature | |
16. | ALA4622323 | T | Toxicity in human HepG2 cells | Homo sapiens | 2 | ALA4619807 | cell-based format | Scientific Literature | |
17. | ALA4622327 | F | Antiasthmatic activity in Aspergillus oryzae protease-mediated C57BL/6J mouse model of allergic asthma assessed as reduction in eosinophil infiltration in bronchoalveolar lavage fluid at 10 mg/kg, ip dosed 30 mins before OVA aerosol challenge and measured 2 days post-challenge by cell differential count assay | Mus musculus | 8 | ALA4619807 | organism-based format | Scientific Literature | |
18. | ALA4622330 | P | Stability in simulated intestinal fluid assessed as compound remaining level at 120 mins | 2 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4622331 | P | Stability in simulated gastric fluid assessed as compound remaining level at 120 mins | 2 | ALA4619807 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4622332 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | ALA4619807 | single protein format | Scientific Literature |