# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4605319 | B | Binding affinity to recombinant human His/FLAG-tagged WDR5 (22 to 334 residues) expressed in Escherichia coli expression system using FITC-AHx-SEEEIDVVSV as substrate by fluorescence polarization assay | Homo sapiens | 31 | ALA4602700 | assay format | Scientific Literature | |
2. | ALA4605320 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in WDR5-MYC interaction at 50 uM incubated for 24 hrs by immunoprecipitation analysis | Homo sapiens | 7 | ALA4602700 | cell-based format | Scientific Literature | |
3. | ALA4605321 | B | Inhibition of WDR5 in human HEK293T cells assessed as reduction in WDR5-MYC interaction at 5 uM incubated for 24 hrs by immunoprecipitation analysis | Homo sapiens | 7 | ALA4602700 | cell-based format | Scientific Literature | |
4. | ALA4605322 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in MYC recruitment C7orf40 binding site at 20 uM incubated for 10 hrs by chromatin immunoprecipitation analysis | Homo sapiens | 1 | ALA4602700 | cell-based format | Scientific Literature | |
5. | ALA4605323 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in MYC recruitment RNPS1 binding site at 20 uM incubated for 10 hrs by chromatin immunoprecipitation analysis | Homo sapiens | 1 | ALA4602700 | cell-based format | Scientific Literature | |
6. | ALA4605324 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in MYC recruitment RPS14 binding site at 20 uM incubated for 10 hrs by chromatin immunoprecipitation analysis | Homo sapiens | 1 | ALA4602700 | cell-based format | Scientific Literature | |
7. | ALA4605325 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in MYC recruitment RPL5 binding site at 20 uM incubated for 10 hrs by chromatin immunoprecipitation analysis | Homo sapiens | 1 | ALA4602700 | cell-based format | Scientific Literature | |
8. | ALA4605326 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in MYC recruitment ZFPM1 binding site at 20 uM incubated for 10 hrs by chromatin immunoprecipitation analysis | Homo sapiens | 1 | ALA4602700 | cell-based format | Scientific Literature | |
9. | ALA4605327 | B | Inhibition of N-terminal FLAG-tagged human full-length WDR5 expressed in HEK293T cells harboring human C-terminal HA-tagged c-MYC assessed as reduction in MYC recruitment ZFM771 binding site at 20 uM incubated for 10 hrs by chromatin immunoprecipitation analysis | Homo sapiens | 1 | ALA4602700 | cell-based format | Scientific Literature | |
10. | ALA4605328 | B | Inhibition of MLL1/WDR5/RBBP5/ASH2L/DPY30 complex (unknown origin) assessed as reduction in histone methyltransferase activity | Homo sapiens | 4 | ALA4602700 | protein format | Scientific Literature | |
11. | ALA5127361 | B | Binding affinity towards N-terminal 6xHis-SUMO tagged human WDR5 (22 to 334 residues) measured by fluorescence polarization assay | Homo sapiens | 2 | ALA5126516 | single protein format | Scientific Literature |