# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4620705 | Binding | Binding affinity to human RORgamma LBD by thermofluor thermal shift assay | Homo sapiens | 68 | ALA4619752 | single protein format | Scientific Literature | |
2. | ALA4620706 | Binding | Inverse agonist activity at human RORgammat LBD by M1H cell based assay | Homo sapiens | 69 | ALA4619752 | cell-based format | Scientific Literature | |
3. | ALA4620707 | Binding | Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A production measured after 3 days by ELISA | Homo sapiens | 48 | ALA4619752 | tissue-based format | Scientific Literature | |
4. | ALA4620708 | Binding | Binding affinity to human RORbeta by thermofluor assay | Homo sapiens | 68 | ALA4619752 | single protein format | Scientific Literature | |
5. | ALA4620709 | Binding | Inverse agonist activity at human RORgammat LBD by M1H cell based assay relative to T0901317 | Homo sapiens | 69 | ALA4619752 | cell-based format | Scientific Literature | |
6. | ALA4620710 | Binding | Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A production at 1 uM measured after 3 days by ELISA relative to JNJ-54271074 | Homo sapiens | 48 | ALA4619752 | tissue-based format | Scientific Literature | |
7. | ALA4620711 | Physicochemical | Solubility of the compound at pH 7 | 53 | ALA4619752 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4620712 | Physicochemical | Solubility of the compound at pH 2 | 51 | ALA4619752 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4620713 | Binding | Activation of PXR (unknown origin) at 1 uM relative to control | Homo sapiens | 62 | ALA4619752 | single protein format | Scientific Literature | |
10. | ALA4620714 | Binding | Activation of PXR (unknown origin) at 5 uM relative to control | Homo sapiens | 56 | ALA4619752 | single protein format | Scientific Literature | |
11. | ALA4620719 | ADME | Half life in rat liver microsomes | Rattus norvegicus | 13 | ALA4619752 | microsome format | Scientific Literature | |
12. | ALA4620720 | ADME | Half life in human liver microsomes | Homo sapiens | 13 | ALA4619752 | microsome format | Scientific Literature | |
13. | ALA4620721 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 11 | ALA4619752 | single protein format | Scientific Literature | |
14. | ALA4620722 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 12 | ALA4619752 | single protein format | Scientific Literature | |
15. | ALA4620723 | ADME | Inhibition of CYP2C8 (unknown origin) | Homo sapiens | 11 | ALA4619752 | single protein format | Scientific Literature | |
16. | ALA4620724 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 12 | ALA4619752 | single protein format | Scientific Literature | |
17. | ALA4620725 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 11 | ALA4619752 | single protein format | Scientific Literature | |
18. | ALA4620726 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 12 | ALA4619752 | single protein format | Scientific Literature | |
19. | ALA4620727 | ADME | Protein binding in human plasma assessed as bound fraction | Homo sapiens | 10 | ALA4619752 | cell-free format | Scientific Literature | |
20. | ALA4620728 | ADME | Protein binding in mouse plasma assessed as bound fraction | Mus musculus | 10 | ALA4619752 | cell-free format | Scientific Literature |