| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4620705 | B | Binding affinity to human RORgamma LBD by thermofluor thermal shift assay | Homo sapiens | 68 | single protein format | Scientific Literature | ||
| 2. | ALA4620706 | B | Inverse agonist activity at human RORgammat LBD by M1H cell based assay | Homo sapiens | 69 | cell-based format | Scientific Literature | ||
| 3. | ALA4620707 | B | Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A production measured after 3 days by ELISA | Homo sapiens | 48 | tissue-based format | Scientific Literature | ||
| 4. | ALA4620708 | B | Binding affinity to human RORbeta by thermofluor assay | Homo sapiens | 68 | single protein format | Scientific Literature | ||
| 5. | ALA4620709 | B | Inverse agonist activity at human RORgammat LBD by M1H cell based assay relative to T0901317 | Homo sapiens | 69 | cell-based format | Scientific Literature | ||
| 6. | ALA4620710 | B | Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A production at 1 uM measured after 3 days by ELISA relative to JNJ-54271074 | Homo sapiens | 48 | tissue-based format | Scientific Literature | ||
| 7. | ALA4620711 | P | Solubility of the compound at pH 7 | 53 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4620712 | P | Solubility of the compound at pH 2 | 51 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4620713 | B | Activation of PXR (unknown origin) at 1 uM relative to control | Homo sapiens | 62 | single protein format | Scientific Literature | ||
| 10. | ALA4620714 | B | Activation of PXR (unknown origin) at 5 uM relative to control | Homo sapiens | 56 | single protein format | Scientific Literature | ||
| 11. | ALA4620719 | A | Half life in rat liver microsomes | Rattus norvegicus | 13 | microsome format | Scientific Literature | ||
| 12. | ALA4620720 | A | Half life in human liver microsomes | Homo sapiens | 13 | microsome format | Scientific Literature | ||
| 13. | ALA4620721 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 14. | ALA4620722 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 15. | ALA4620723 | A | Inhibition of CYP2C8 (unknown origin) | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 16. | ALA4620724 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 17. | ALA4620725 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 18. | ALA4620726 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 19. | ALA4620727 | A | Protein binding in human plasma assessed as bound fraction | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
| 20. | ALA4620728 | A | Protein binding in mouse plasma assessed as bound fraction | Mus musculus | 10 | cell-free format | Scientific Literature |
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