# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4610601 | Binding | Inhibition of KDM4C (unknown origin) using methylated H3 peptide as substrate by chemiluminescence assay | Homo sapiens | 15 | ALA4609995 | single protein format | Scientific Literature | |
2. | ALA4610602 | ADME | Substrate activity at P-gp in MDCK2-MDR1 cells at 10 uM incubated for 60 mins in presence or absence of 2 uM P-gp inhibitor elacridar by LC-MS/MS analysis | Canis lupus familiaris | 15 | ALA4609995 | cell-based format | Scientific Literature | |
3. | ALA4610604 | Functional | Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay | Homo sapiens | 15 | ALA4609995 | cell-based format | Scientific Literature | |
4. | ALA4610605 | Functional | Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay | Homo sapiens | 15 | ALA4609995 | cell-based format | Scientific Literature | |
5. | ALA4610606 | ADME | Permeability across apical to basolateral side in MDCK2-MDR1 cells at 10 uM incubated for 60 mins in presence 2 uM P-gp inhibitor elacridar by LC-MS/MS analysis | Canis lupus familiaris | 15 | ALA4609995 | cell-based format | Scientific Literature | |
6. | ALA4610607 | ADME | Intrinsic clearance in mouse liver microsomes assessed per mg protein at 1 uM measured up to 60 mins in presence or absence of NADPH by LC-MS/MS analysis | Mus musculus | 15 | ALA4609995 | microsome format | Scientific Literature | |
7. | ALA4610608 | ADME | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in MDCK2-MDR1 cells MDCK2-MDR1 cells at 10 uM incubated for 60 mins in presence 2 uM P-gp inhibitor elacridar by LC-MS/MS analysis | Canis lupus familiaris | 15 | ALA4609995 | cell-based format | Scientific Literature |